Modulation of oscillatory power and connectivity in the human posterior cingulate cortex supports the encoding and retrieval of episodic memories

Bradley Lega, James Germi, Michael Rugg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Existing data from noninvasive studies have led researchers to posit that the posterior cingulate cortex (PCC) supports mnemonic processes: It exhibits degeneration in memory disorders, and fMRI investigations have demonstrated memoryrelated activation principally during the retrieval of memory items. Despite these data, the role of the PCC in episodic memory has received only limited treatment using the spatial and temporal precision of intracranial EEG, with previous analyses focused on item retrieval. Using data gathered from 21 human participants who underwent stereo-EEG for seizure localization, we characterized oscillatory patterns in the PCC during the encoding and retrieval of episodic memories. We identified a subsequent memory effect during item encoding characterized by increased gamma band oscillatory power and a low-frequency power desynchronization. Fourteen participants had stereotactic electrodes located simultaneously in the hippocampus and PCC, and with these unique data, we describe connectivity changes between these structures that predict successful item encoding and that precede item retrieval. Oscillatory power during retrieval matched the pattern we observed during encoding, with lowfrequency (below 15 Hz) desynchronization and a gamma band (especially high gamma, 70–180 Hz) power increase. Encoding is characterized by synchrony between the hippocampus and PCC, centered at 3 Hz, consistent with other observations of properties of this oscillation akin to those for rodent theta activity. We discuss our findings in light of existing theories of episodic memory processing, including the information via desynchronization hypothesis and retrieved context theory, and examine how our data fit with existing theories for the functional role of the PCC. These include a postulated role for the PCC in modulating internally directed attention and for representing or integrating contextual information for memory items.

Original languageEnglish (US)
Pages (from-to)1415-1432
Number of pages18
JournalJournal of Cognitive Neuroscience
Volume29
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Episodic Memory
Gyrus Cinguli
Hippocampus
seizure
Memory Disorders
Power (Psychology)
Encoding
Connectivity
Modulation
Cortex
Automatic Data Processing
activation
Electroencephalography
Rodentia
Electrodes
Seizures
Research Personnel
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience

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Modulation of oscillatory power and connectivity in the human posterior cingulate cortex supports the encoding and retrieval of episodic memories. / Lega, Bradley; Germi, James; Rugg, Michael.

In: Journal of Cognitive Neuroscience, Vol. 29, No. 8, 01.08.2017, p. 1415-1432.

Research output: Contribution to journalArticle

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