Abstract
Tilorone (2,7-bis[(diethylamino)ethoxy]fluoren-9-one) can enhance the humoral immune response of mice to SRBC although Tilorone has no effect on functional activity of splenic B cells in the absence of immunogen. Tilorone does not alter the effective level of T cell help but does seem to alter the level of effective suppression. Tilorone seems to be an adjuvant only in the sense of removing a normal homeostatic control mechanism, perhaps suppressor T cells.
Original language | English (US) |
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Pages (from-to) | 29-37 |
Number of pages | 9 |
Journal | Immunopharmacology |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1978 |
Keywords
- Immune response
- Tilorone
ASJC Scopus subject areas
- Pharmacology