Modulation of the acquisition and expression of immunity by tilorone: II. Humoral responsiveness

John R. Kettman

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Tilorone (2,7-bis[(diethylamino)ethoxy]fluoren-9-one) can enhance the humoral immune response of mice to SRBC although Tilorone has no effect on functional activity of splenic B cells in the absence of immunogen. Tilorone does not alter the effective level of T cell help but does seem to alter the level of effective suppression. Tilorone seems to be an adjuvant only in the sense of removing a normal homeostatic control mechanism, perhaps suppressor T cells.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalImmunopharmacology
Volume1
Issue number1
DOIs
StatePublished - Dec 1978

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Keywords

  • Immune response
  • Tilorone

ASJC Scopus subject areas

  • Pharmacology

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