Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network

Research output: Contribution to journalReview article

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Abstract

Over the past century, prevalent models of energy and glucose homeostasis have been developed from a better understanding of the neural circuits underlying obesity and diabetes. From the early hypothalamic lesion reports to the more recent pharmacological and molecular/genetic studies, the hypothalamic melanocortin system has been shown to play a critical role in the regulation of metabolism. This review attempts to highlight contributions to our current understanding of how numerous neuromodulators (leptin, insulin, and serotonin) integrate with the central melanocortin system to coordinate alterations in energy and glucose balance.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalEuropean Journal of Pharmacology
Volume660
Issue number1
DOIs
StatePublished - Jun 11 2011

Keywords

  • Diabetes
  • Insulin
  • Leptin
  • Obesity
  • Patch-clamp
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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