Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

S. James Ratnakar, Mark Woods, Angelo J M Lubag, Zoltán Kovács, A. Dean Sherry

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Abstract

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F CO2 tBu < CN H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

Original languageEnglish (US)
Pages (from-to)6-7
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number1
DOIs
Publication statusPublished - Jan 9 2008

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ASJC Scopus subject areas

  • Chemistry(all)

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