Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

S. James Ratnakar, Mark Woods, Angelo J M Lubag, Zoltán Kovács, A. Dean Sherry

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F CO2tBu < CN H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

Original languageEnglish (US)
Pages (from-to)6-7
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number1
DOIs
StatePublished - Jan 9 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects'. Together they form a unique fingerprint.

Cite this