Molecular architecture of the mammalian circadian clock

Research output: Contribution to journalArticle

485 Scopus citations

Abstract

Circadian clocks coordinate physiology and behavior with the 24. h solar day to provide temporal homeostasis with the external environment. The molecular clocks that drive these intrinsic rhythmic changes are based on interlocked transcription/translation feedback loops that integrate with diverse environmental and metabolic stimuli to generate internal 24. h timing. In this review we highlight recent advances in our understanding of the core molecular clock and how it utilizes diverse transcriptional and post-transcriptional mechanisms to impart temporal control onto mammalian physiology. Understanding the way in which biological rhythms are generated throughout the body may provide avenues for temporally directed therapeutics to improve health and prevent disease.

Original languageEnglish (US)
Pages (from-to)90-99
Number of pages10
JournalTrends in Cell Biology
Volume24
Issue number2
DOIs
StatePublished - Feb 2014

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Keywords

  • Circadian
  • Peripheral clock
  • Post-transcription
  • Transcription

ASJC Scopus subject areas

  • Cell Biology

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