Molecular basis of lung carcinogenesis

Kwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, John D. Minna

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lung cancer is the most prevalent cancer and the largest cause of cancer deaths in the Western world. Smoking is the major carcinogen for lung cancer but only approximately 15 % of smokers develop lung cancer, suggesting individual differences in susceptibility to tobacco smoke carcinogens. Once invasive, survival from lung cancer is poor which necessitates the prompt development of new therapeutic strategies in addition to effective methods for early detection, chemoprevention, and smoking cessation. Modern diagnostic and therapeutic strategies are becoming more realistic with the greater understanding of the molecular basis of lung cancer including the role of genomics and epigenomics in its pathogenesis. One such example of the benefits that result from expanded knowledge includes the advent of new targeted therapies, which are becoming increasingly used in clinical practice.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages447-496
Number of pages50
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

Fingerprint

Lung Neoplasms
Carcinogenesis
Lung
Carcinogens
Western World
Chemoprevention
Smoking Cessation
Genomics
Epigenomics
Individuality
Smoke
Tobacco
Cause of Death
Neoplasms
Therapeutics
Smoking

Keywords

  • Genetic loss in lung cancer
  • Growth inhibition
  • Lung cancer
  • Lung carcinogenesis
  • Oncogenes
  • Overt lung cancers
  • Smoking
  • Smoking cessation
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fong, K. M., Larsen, J. E., Wright, C., Sriram, K., Davidson, M., Daniels, M., ... Minna, J. D. (2016). Molecular basis of lung carcinogenesis. In The Molecular Basis of Human Cancer (pp. 447-496). Springer New York. https://doi.org/10.1007/978-1-59745-458-2_28

Molecular basis of lung carcinogenesis. / Fong, Kwun M.; Larsen, Jill E.; Wright, Casey; Sriram, Krishna; Davidson, Morgan; Daniels, Marissa; Sekido, Yoshitaka; Bowman, Rayleen V.; Yang, Ian A.; Minna, John D.

The Molecular Basis of Human Cancer. Springer New York, 2016. p. 447-496.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fong, KM, Larsen, JE, Wright, C, Sriram, K, Davidson, M, Daniels, M, Sekido, Y, Bowman, RV, Yang, IA & Minna, JD 2016, Molecular basis of lung carcinogenesis. in The Molecular Basis of Human Cancer. Springer New York, pp. 447-496. https://doi.org/10.1007/978-1-59745-458-2_28
Fong KM, Larsen JE, Wright C, Sriram K, Davidson M, Daniels M et al. Molecular basis of lung carcinogenesis. In The Molecular Basis of Human Cancer. Springer New York. 2016. p. 447-496 https://doi.org/10.1007/978-1-59745-458-2_28
Fong, Kwun M. ; Larsen, Jill E. ; Wright, Casey ; Sriram, Krishna ; Davidson, Morgan ; Daniels, Marissa ; Sekido, Yoshitaka ; Bowman, Rayleen V. ; Yang, Ian A. ; Minna, John D. / Molecular basis of lung carcinogenesis. The Molecular Basis of Human Cancer. Springer New York, 2016. pp. 447-496
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