Molecular basis of lung carcinogenesis

Kwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, John D. Minna

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Lung cancer is the most prevalent cancer and the largest cause of cancer deaths in the Western world. Smoking is the major carcinogen for lung cancer but only approximately 15 % of smokers develop lung cancer, suggesting individual differences in susceptibility to tobacco smoke carcinogens. Once invasive, survival from lung cancer is poor which necessitates the prompt development of new therapeutic strategies in addition to effective methods for early detection, chemoprevention, and smoking cessation. Modern diagnostic and therapeutic strategies are becoming more realistic with the greater understanding of the molecular basis of lung cancer including the role of genomics and epigenomics in its pathogenesis. One such example of the benefits that result from expanded knowledge includes the advent of new targeted therapies, which are becoming increasingly used in clinical practice.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages447-496
Number of pages50
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

Keywords

  • Genetic loss in lung cancer
  • Growth inhibition
  • Lung cancer
  • Lung carcinogenesis
  • Oncogenes
  • Overt lung cancers
  • Smoking
  • Smoking cessation
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Medicine(all)

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