TY - JOUR
T1 - Molecular Biology of Lung Cancer
T2 - Clinical Implications
AU - Larsen, Jill E.
AU - Minna, John D.
N1 - Funding Information:
This research was supported by: National Cancer Institute Lung Cancer Specialized Program of Research Excellence (SPORE ) ( P50CA70907 ), Department of Defense VITAL ( W81XWH0410142 ) and PROSPECT ( W81XWH0710306 ), NASA NSCOR ( NNJ05HD36G ) and by the Office of Science (BER) U.S. Department of Energy , Grant Number DEAI02-05ER64068 . J.E.L. is supported by an NH&MRC Biomedical Fellowship (494511).
PY - 2011/12
Y1 - 2011/12
N2 - Lung cancer is a heterogeneous disease clinically, biologically, histologically, and molecularly. Understanding the molecular causes of this heterogeneity, which might reflect changes occurring in different classes of epithelial cells or different molecular changes occurring in the same target lung epithelial cells, is the focus of current research. Identifying the genes and pathways involved, determining how they relate to the biological behavior of lung cancer, and their utility as diagnostic and therapeutic targets are important basic and translational research issues. This article reviews current information on the key molecular steps in lung cancer pathogenesis, their timing, and clinical implications.
AB - Lung cancer is a heterogeneous disease clinically, biologically, histologically, and molecularly. Understanding the molecular causes of this heterogeneity, which might reflect changes occurring in different classes of epithelial cells or different molecular changes occurring in the same target lung epithelial cells, is the focus of current research. Identifying the genes and pathways involved, determining how they relate to the biological behavior of lung cancer, and their utility as diagnostic and therapeutic targets are important basic and translational research issues. This article reviews current information on the key molecular steps in lung cancer pathogenesis, their timing, and clinical implications.
KW - Gene mutation
KW - Genome-wide analysis
KW - Lung cancer
KW - Lung carcinogenesis
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U2 - 10.1016/j.ccm.2011.08.003
DO - 10.1016/j.ccm.2011.08.003
M3 - Review article
C2 - 22054881
AN - SCOPUS:80555134650
SN - 0272-5231
VL - 32
SP - 703
EP - 740
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 4
ER -