Molecular cloning and characterization of alpha-subunit isoforms of the Na,K-ATPase.

R. W. Mercer, Jay W Schneider, E. J. Benz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The identification of the different alpha-subunit isoforms of the Na,K-ATPase has added an unexpected complexity to the understanding of the function and regulation of this important transport protein. Our results indicate that the alpha, alpha(+) and alpha III isoform mRNAs have distinct, but partially overlapping, distributions in brain and peripheral tissues. Also, characterization of mRNA distribution in fetal tissues suggests that the Na,K-ATPase alpha-subunit isoforms are regulated during development and differentiation. The developmental regulation and strikingly different tissue specificities of the three alpha-subunit isoforms suggests that the different Na,K-ATPase alpha-subunits may be adapted to perform different roles in maintaining sodium and potassium homeostasis.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalProgress in clinical and biological research
Volume268 B
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Molecular Cloning
Protein Isoforms
RNA Isoforms
Organ Specificity
Potassium
Carrier Proteins
Fetus
Homeostasis
Sodium
Messenger RNA
Brain
sodium-translocating ATPase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular cloning and characterization of alpha-subunit isoforms of the Na,K-ATPase. / Mercer, R. W.; Schneider, Jay W; Benz, E. J.

In: Progress in clinical and biological research, Vol. 268 B, 01.01.1988, p. 119-126.

Research output: Contribution to journalArticle

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