Molecular definitions of autophagy and related processes

Lorenzo Galluzzi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Francesco Cecconi, Augustine M. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Jayanta Debnath, Vojo Deretic, Ivan Dikic, Eeva Liisa Eskelinen, Gian Maria Fimia, Simone Fulda, David A. Gewirtz, Douglas R. Green, Malene HansenJ. Wade Harper, Marja Jäättelä, Terje Johansen, Gabor Juhasz, Alec C. Kimmelman, Claudine Kraft, Nicholas T. Ktistakis, Sharad Kumar, Beth Levine, Carlos Lopez-Otin, Frank Madeo, Sascha Martens, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Münz, Leon O. Murphy, Josef M. Penninger, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Laura Santambrogio, Luca Scorrano, Anna Katharina Simon, Hans Uwe Simon, Anne Simonsen, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Guido Kroemer

Research output: Contribution to journalReview article

291 Citations (Scopus)

Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Original languageEnglish (US)
Pages (from-to)1811-1836
Number of pages26
JournalEMBO Journal
Volume36
Issue number13
DOIs
StatePublished - Jul 3 2017

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Autophagy
Machinery
Research

Keywords

  • chaperone-mediated autophagy
  • LC3-associated phagocytosis
  • microautophagy
  • mitophagy
  • xenophagy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo-San Pedro, J. M., Cecconi, F., ... Kroemer, G. (2017). Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), 1811-1836. https://doi.org/10.15252/embj.201796697

Molecular definitions of autophagy and related processes. / Galluzzi, Lorenzo; Baehrecke, Eric H.; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cecconi, Francesco; Choi, Augustine M.; Chu, Charleen T.; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Debnath, Jayanta; Deretic, Vojo; Dikic, Ivan; Eskelinen, Eeva Liisa; Fimia, Gian Maria; Fulda, Simone; Gewirtz, David A.; Green, Douglas R.; Hansen, Malene; Harper, J. Wade; Jäättelä, Marja; Johansen, Terje; Juhasz, Gabor; Kimmelman, Alec C.; Kraft, Claudine; Ktistakis, Nicholas T.; Kumar, Sharad; Levine, Beth; Lopez-Otin, Carlos; Madeo, Frank; Martens, Sascha; Martinez, Jennifer; Melendez, Alicia; Mizushima, Noboru; Münz, Christian; Murphy, Leon O.; Penninger, Josef M.; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C.; Ryan, Kevin M.; Santambrogio, Laura; Scorrano, Luca; Simon, Anna Katharina; Simon, Hans Uwe; Simonsen, Anne; Tavernarakis, Nektarios; Tooze, Sharon A.; Yoshimori, Tamotsu; Yuan, Junying; Yue, Zhenyu; Zhong, Qing; Kroemer, Guido.

In: EMBO Journal, Vol. 36, No. 13, 03.07.2017, p. 1811-1836.

Research output: Contribution to journalReview article

Galluzzi, L, Baehrecke, EH, Ballabio, A, Boya, P, Bravo-San Pedro, JM, Cecconi, F, Choi, AM, Chu, CT, Codogno, P, Colombo, MI, Cuervo, AM, Debnath, J, Deretic, V, Dikic, I, Eskelinen, EL, Fimia, GM, Fulda, S, Gewirtz, DA, Green, DR, Hansen, M, Harper, JW, Jäättelä, M, Johansen, T, Juhasz, G, Kimmelman, AC, Kraft, C, Ktistakis, NT, Kumar, S, Levine, B, Lopez-Otin, C, Madeo, F, Martens, S, Martinez, J, Melendez, A, Mizushima, N, Münz, C, Murphy, LO, Penninger, JM, Piacentini, M, Reggiori, F, Rubinsztein, DC, Ryan, KM, Santambrogio, L, Scorrano, L, Simon, AK, Simon, HU, Simonsen, A, Tavernarakis, N, Tooze, SA, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q & Kroemer, G 2017, 'Molecular definitions of autophagy and related processes', EMBO Journal, vol. 36, no. 13, pp. 1811-1836. https://doi.org/10.15252/embj.201796697
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F et al. Molecular definitions of autophagy and related processes. EMBO Journal. 2017 Jul 3;36(13):1811-1836. https://doi.org/10.15252/embj.201796697
Galluzzi, Lorenzo ; Baehrecke, Eric H. ; Ballabio, Andrea ; Boya, Patricia ; Bravo-San Pedro, José Manuel ; Cecconi, Francesco ; Choi, Augustine M. ; Chu, Charleen T. ; Codogno, Patrice ; Colombo, Maria Isabel ; Cuervo, Ana Maria ; Debnath, Jayanta ; Deretic, Vojo ; Dikic, Ivan ; Eskelinen, Eeva Liisa ; Fimia, Gian Maria ; Fulda, Simone ; Gewirtz, David A. ; Green, Douglas R. ; Hansen, Malene ; Harper, J. Wade ; Jäättelä, Marja ; Johansen, Terje ; Juhasz, Gabor ; Kimmelman, Alec C. ; Kraft, Claudine ; Ktistakis, Nicholas T. ; Kumar, Sharad ; Levine, Beth ; Lopez-Otin, Carlos ; Madeo, Frank ; Martens, Sascha ; Martinez, Jennifer ; Melendez, Alicia ; Mizushima, Noboru ; Münz, Christian ; Murphy, Leon O. ; Penninger, Josef M. ; Piacentini, Mauro ; Reggiori, Fulvio ; Rubinsztein, David C. ; Ryan, Kevin M. ; Santambrogio, Laura ; Scorrano, Luca ; Simon, Anna Katharina ; Simon, Hans Uwe ; Simonsen, Anne ; Tavernarakis, Nektarios ; Tooze, Sharon A. ; Yoshimori, Tamotsu ; Yuan, Junying ; Yue, Zhenyu ; Zhong, Qing ; Kroemer, Guido. / Molecular definitions of autophagy and related processes. In: EMBO Journal. 2017 ; Vol. 36, No. 13. pp. 1811-1836.
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AU - Ballabio, Andrea

AU - Boya, Patricia

AU - Bravo-San Pedro, José Manuel

AU - Cecconi, Francesco

AU - Choi, Augustine M.

AU - Chu, Charleen T.

AU - Codogno, Patrice

AU - Colombo, Maria Isabel

AU - Cuervo, Ana Maria

AU - Debnath, Jayanta

AU - Deretic, Vojo

AU - Dikic, Ivan

AU - Eskelinen, Eeva Liisa

AU - Fimia, Gian Maria

AU - Fulda, Simone

AU - Gewirtz, David A.

AU - Green, Douglas R.

AU - Hansen, Malene

AU - Harper, J. Wade

AU - Jäättelä, Marja

AU - Johansen, Terje

AU - Juhasz, Gabor

AU - Kimmelman, Alec C.

AU - Kraft, Claudine

AU - Ktistakis, Nicholas T.

AU - Kumar, Sharad

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AU - Lopez-Otin, Carlos

AU - Madeo, Frank

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AU - Martinez, Jennifer

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