Molecular definitions of cell death subroutines

Recommendations of the Nomenclature Committee on Cell Death 2012

L. Galluzzi, I. Vitale, J. M. Abrams, E. S. Alnemri, E. H. Baehrecke, M. V. Blagosklonny, T. M. Dawson, V. L. Dawson, W. S. El-Deiry, S. Fulda, E. Gottlieb, D. R. Green, M. O. Hengartner, O. Kepp, R. A. Knight, S. Kumar, S. A. Lipton, X. Lu, F. Madeo, W. Malorni & 13 others P. Mehlen, G. Nũez, M. E. Peter, M. Piacentini, D. C. Rubinsztein, Y. Shi, H. U. Simon, P. Vandenabeele, E. White, J. Yuan, B. Zhivotovsky, G. Melino, G. Kroemer

Research output: Contribution to journalArticle

1489 Citations (Scopus)

Abstract

In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including apoptosis, necrosis and mitotic catastrophe. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or-independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features.

Original languageEnglish (US)
Pages (from-to)107-120
Number of pages14
JournalCell Death and Differentiation
Volume19
Issue number1
DOIs
StatePublished - Jan 2012

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Terminology
Cell Death
Apoptosis
Necrosis
Autophagy
Caspases
Molecular Biology

Keywords

  • autophagy
  • mitochondrial membrane permeabilization
  • necroptosis
  • parthanatos
  • TNFR1
  • TP53

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Molecular definitions of cell death subroutines : Recommendations of the Nomenclature Committee on Cell Death 2012. / Galluzzi, L.; Vitale, I.; Abrams, J. M.; Alnemri, E. S.; Baehrecke, E. H.; Blagosklonny, M. V.; Dawson, T. M.; Dawson, V. L.; El-Deiry, W. S.; Fulda, S.; Gottlieb, E.; Green, D. R.; Hengartner, M. O.; Kepp, O.; Knight, R. A.; Kumar, S.; Lipton, S. A.; Lu, X.; Madeo, F.; Malorni, W.; Mehlen, P.; Nũez, G.; Peter, M. E.; Piacentini, M.; Rubinsztein, D. C.; Shi, Y.; Simon, H. U.; Vandenabeele, P.; White, E.; Yuan, J.; Zhivotovsky, B.; Melino, G.; Kroemer, G.

In: Cell Death and Differentiation, Vol. 19, No. 1, 01.2012, p. 107-120.

Research output: Contribution to journalArticle

Galluzzi, L, Vitale, I, Abrams, JM, Alnemri, ES, Baehrecke, EH, Blagosklonny, MV, Dawson, TM, Dawson, VL, El-Deiry, WS, Fulda, S, Gottlieb, E, Green, DR, Hengartner, MO, Kepp, O, Knight, RA, Kumar, S, Lipton, SA, Lu, X, Madeo, F, Malorni, W, Mehlen, P, Nũez, G, Peter, ME, Piacentini, M, Rubinsztein, DC, Shi, Y, Simon, HU, Vandenabeele, P, White, E, Yuan, J, Zhivotovsky, B, Melino, G & Kroemer, G 2012, 'Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012', Cell Death and Differentiation, vol. 19, no. 1, pp. 107-120. https://doi.org/10.1038/cdd.2011.96
Galluzzi, L. ; Vitale, I. ; Abrams, J. M. ; Alnemri, E. S. ; Baehrecke, E. H. ; Blagosklonny, M. V. ; Dawson, T. M. ; Dawson, V. L. ; El-Deiry, W. S. ; Fulda, S. ; Gottlieb, E. ; Green, D. R. ; Hengartner, M. O. ; Kepp, O. ; Knight, R. A. ; Kumar, S. ; Lipton, S. A. ; Lu, X. ; Madeo, F. ; Malorni, W. ; Mehlen, P. ; Nũez, G. ; Peter, M. E. ; Piacentini, M. ; Rubinsztein, D. C. ; Shi, Y. ; Simon, H. U. ; Vandenabeele, P. ; White, E. ; Yuan, J. ; Zhivotovsky, B. ; Melino, G. ; Kroemer, G. / Molecular definitions of cell death subroutines : Recommendations of the Nomenclature Committee on Cell Death 2012. In: Cell Death and Differentiation. 2012 ; Vol. 19, No. 1. pp. 107-120.
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