Molecular genetic abnormalities in the pathogenesis of human lung cancer

E. Forgacs, S. Zöchbauer-Müller, E. Oláh, J. D. Minna

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

In the past few years our knowledge of the molecular pathogenesis of lung cancer has significantly increased. There are several molecular mechanisms involved in the multistage carcinogenesis through which respiratory epithelial cells become preneoplastic and then invasive cancer. In this review we summarize some of these changes including, genomic alterations such as loss of heterozygosity and microsatellite alterations, autocrine-paracrine loops, alterations in oncogenes and tumor suppressor genes, tumor angiogenesis, aberrant promoter methylation and inherited predisposition to lung cancer. Translation of these findings to the clinic is also discussed.

Original languageEnglish (US)
Pages (from-to)6-13
Number of pages8
JournalPathology and Oncology Research
Volume7
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Angiogenesis
  • Autocrine
  • Cell cycle
  • Methylation
  • Mutation
  • Oncogene
  • Preneoplasia
  • Signal transduction
  • Telomerase
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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