Molecular genetics of familial renal cell carcinoma syndromes

David Cohen, Ming Zhou

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


RCC represents a group of clinically and genetically diverse diseases. Familial RCC syndromes, although rare, provide an invaluable model to study the molecular mechanisms of renal carcinogenesis. Many causative oncogenes and tumor suppressor genes have been identified and it is now possible to identify the affected individuals and carriers by genetic testing. Understanding of the molecular pathways of these genes will have a significant impact on the diagnosis and treatment of familial and sporadic RCC.

Original languageEnglish (US)
Pages (from-to)259-277
Number of pages19
JournalClinics in laboratory medicine
Issue number2
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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