Molecular Genetics of Lung Cancer

Yoshitaka Sekido, Kwun M. Fong, John D. Minna

Research output: Contribution to journalArticle

254 Citations (Scopus)

Abstract

Lung cancer results from multiple changes in the genome of susceptible pulmonary cells caused by exposure to carcinogens found in tobacco smoke, the environment, or the workplace. Recent studies suggest that histologically apparent lung cancer is due to the sequential accumulation of specific genetic and morphologic changes to the normal epithelial cells of the lung. Positive signallers, such as those mediated by the oncogene RAS, and negative signallers, such as those mediated by the tumor suppressor retinoblastoma protein (RB), contribute to unchecked cell growth and proliferation. Other key molecular derangements can also be considered hallmarks of cancer, including evasion of apoptosis and senescence, angiogenesis, tissue invasion, and metastases. Epigenetic inactivation of genes via DNA methylation provides another novel way of evading normal cellular control mechanisms. The new knowledge of the human genome coupled with global methods of detecting genetic abnormalities and profiling gene expression in tumor cells may enable us to understand the signaling pathways of lung cancer cells. These are molecular targets for new cancer therapeutics such as receptor tyrosine kinase inhibitors. This information could advance risk assessment, early detection, prognosis, and therapy for lung cancer.

Original languageEnglish (US)
Pages (from-to)73-87
Number of pages15
JournalAnnual Review of Medicine
Volume54
DOIs
StatePublished - 2003

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Molecular Biology
Lung Neoplasms
Genes
Tumors
Cells
Retinoblastoma Protein
Tobacco
Cell proliferation
Receptor Protein-Tyrosine Kinases
Cell growth
Tumor Suppressor Proteins
Gene expression
Smoke
Carcinogens
Neoplasms
Risk assessment
Lung
Gene Silencing
Gene Expression Profiling
Human Genome

Keywords

  • Epigenetics
  • Mutation
  • Oncogene
  • Pathogenesis
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Molecular Genetics of Lung Cancer. / Sekido, Yoshitaka; Fong, Kwun M.; Minna, John D.

In: Annual Review of Medicine, Vol. 54, 2003, p. 73-87.

Research output: Contribution to journalArticle

Sekido, Yoshitaka ; Fong, Kwun M. ; Minna, John D. / Molecular Genetics of Lung Cancer. In: Annual Review of Medicine. 2003 ; Vol. 54. pp. 73-87.
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