TY - JOUR
T1 - Molecular Imaging and Precision Medicine in Head and Neck Cancer
AU - Mena, Esther
AU - Thippsandra, Shwetha
AU - Yanamadala, Anusha
AU - Redy, Siddaling
AU - Pattanayak, Puskar
AU - Subramaniam, Rathan M.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.
AB - The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.
KW - Head and neck cancer
KW - Molecular imaging
KW - Targeted therapy
KW - Tumor genetic profiling
UR - http://www.scopus.com/inward/record.url?scp=85001967887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85001967887&partnerID=8YFLogxK
U2 - 10.1016/j.cpet.2016.08.009
DO - 10.1016/j.cpet.2016.08.009
M3 - Review article
C2 - 27863568
AN - SCOPUS:85001967887
SN - 1556-8598
VL - 12
SP - 7
EP - 25
JO - PET Clinics
JF - PET Clinics
IS - 1
ER -