Molecular Imaging and Precision Medicine in Head and Neck Cancer

Esther Mena, Shwetha Thippsandra, Anusha Yanamadala, Siddaling Redy, Puskar Pattanayak, Rathan M. Subramaniam

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment. This review summarizes recent genomic discoveries in HN cancer and their implications for functional PET imaging in assessing response to targeted therapies, and drug resistance mechanisms.

Original languageEnglish (US)
Pages (from-to)7-25
Number of pages19
JournalPET Clinics
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Head and neck cancer
  • Molecular imaging
  • Targeted therapy
  • Tumor genetic profiling

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Mena, E., Thippsandra, S., Yanamadala, A., Redy, S., Pattanayak, P., & Subramaniam, R. M. (2017). Molecular Imaging and Precision Medicine in Head and Neck Cancer. PET Clinics, 12(1), 7-25. https://doi.org/10.1016/j.cpet.2016.08.009