Molecular imaging in prostate cancer

Jose A. Karam, Ralph P. Mason, Kenneth S. Koeneman, Peter P. Antich, Elie A. Benaim, Jer Tsong Hsieh

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Prostate cancer (PCa) is the most common non-cutaneous malignancy in men. New ways to diagnose this cancer in its early stages are needed. Unique genetic and biochemical changes in the cell pave the way for tumors to grow and metastasize. Novel imaging approaches attempt to detect pathological processes in cancer cells at the molecular level. This has led to the establishment and development of the field of molecular imaging. Positron emission (PET), magnetic resonance spectroscopic imaging (MRSI), magnetic resonance imaging (MRI), and radiolabeled antibodies are a few of the modalities that can detect abnormal tumor metabolic processes in the clinical setting. Other imaging techniques are still in their early phase of development but hold promise for the future, including bioluminescence imaging (BLI), measurement of tumor oxygenation, and measurement of uptake of iodine by tumors. These techniques are non-invasive and can spare the patient undue morbidity, while potentially providing early diagnosis, accurate follow-up and, finally, valuable prognostic information.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
JournalJournal of Cellular Biochemistry
Volume90
Issue number3
DOIs
StatePublished - Oct 15 2003

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Keywords

  • Bioluminescence
  • MRI
  • Molecular imaging
  • PET
  • Prostate cancer
  • Radiolabeled antibodies
  • Tumor oximetry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Karam, J. A., Mason, R. P., Koeneman, K. S., Antich, P. P., Benaim, E. A., & Hsieh, J. T. (2003). Molecular imaging in prostate cancer. Journal of Cellular Biochemistry, 90(3), 473-483. https://doi.org/10.1002/jcb.10636