Molecular Markers and Genetics in Cancer Development

Kathy Hormi-Carver; Rhonda F. Souza

doi:10.1016/j.soc.2009.03.002

Molecular Markers and Genetics in Cancer Development

Kathy Hormi-Carver, Rhonda F. Souza

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.

Original language	English (US)
Pages (from-to)	453-467
Number of pages	15
Journal	Surgical Oncology Clinics of North America
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.soc.2009.03.002
State	Published - Jul 2009

Keywords

Aneuploidy
Barrett's esophagus
Biomarkers
Esophageal adenocarcinoma
Stem cell

ASJC Scopus subject areas

Surgery
Oncology

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10.1016/j.soc.2009.03.002

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abstract = "This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.",

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AU - Souza, Rhonda F.

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AB - This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.

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KW - Barrett's esophagus

KW - Biomarkers

KW - Esophageal adenocarcinoma

KW - Stem cell

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Molecular Markers and Genetics in Cancer Development

Abstract

Keywords

ASJC Scopus subject areas

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