Molecular Markers and Genetics in Cancer Development

Kathy Hormi-Carver, Rhonda F. Souza

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.

Original languageEnglish (US)
Pages (from-to)453-467
Number of pages15
JournalSurgical Oncology Clinics of North America
Volume18
Issue number3
DOIs
StatePublished - Jul 1 2009

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Keywords

  • Aneuploidy
  • Barrett's esophagus
  • Biomarkers
  • Esophageal adenocarcinoma
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Oncology

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