Molecular mechanisms controlling the migration of striatal interneurons

Verona Villar-Cerviño, Caroline Kappeler, Sandrina Nóbrega-Pereira, Mark Henkemeyer, Luciano Rago, M. Angela Nieto, Oscar Marín

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In the developing telencephalon, the medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While the molecular mechanisms controlling the migration of interneurons to the cortex have been extensively studied, very little is known about the nature of the signals that guide interneurons to the striatum. Here we report that the allocation of MGE-derived interneurons in the developing striatum of the mouse relies on a combination of chemoattractive and chemorepulsive activities. Specifically, interneurons migrate toward the striatum in response to Nrg1/ErbB4 chemoattraction, and avoid migrating into the adjacent cortical territories by a repulsive activity mediated by EphB/ephrinB signaling. Our results also suggest that the responsiveness of MGE-derived striatal interneurons to these cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1. This study therefore reveals parallel mechanisms for the migration of MGE-derived interneurons to the striatum and the cerebral cortex.

Original languageEnglish (US)
Pages (from-to)8718-8729
Number of pages12
JournalJournal of Neuroscience
Volume35
Issue number23
DOIs
StatePublished - 2015

Fingerprint

Corpus Striatum
Interneurons
Median Eminence
Telencephalon
Cerebral Cortex
Cues
Transcription Factors

Keywords

  • Eph
  • ErbB4
  • GABAergic
  • Interneuron
  • Migration
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Villar-Cerviño, V., Kappeler, C., Nóbrega-Pereira, S., Henkemeyer, M., Rago, L., Nieto, M. A., & Marín, O. (2015). Molecular mechanisms controlling the migration of striatal interneurons. Journal of Neuroscience, 35(23), 8718-8729. https://doi.org/10.1523/JNEUROSCI.4317-14.2015

Molecular mechanisms controlling the migration of striatal interneurons. / Villar-Cerviño, Verona; Kappeler, Caroline; Nóbrega-Pereira, Sandrina; Henkemeyer, Mark; Rago, Luciano; Nieto, M. Angela; Marín, Oscar.

In: Journal of Neuroscience, Vol. 35, No. 23, 2015, p. 8718-8729.

Research output: Contribution to journalArticle

Villar-Cerviño, V, Kappeler, C, Nóbrega-Pereira, S, Henkemeyer, M, Rago, L, Nieto, MA & Marín, O 2015, 'Molecular mechanisms controlling the migration of striatal interneurons', Journal of Neuroscience, vol. 35, no. 23, pp. 8718-8729. https://doi.org/10.1523/JNEUROSCI.4317-14.2015
Villar-Cerviño, Verona ; Kappeler, Caroline ; Nóbrega-Pereira, Sandrina ; Henkemeyer, Mark ; Rago, Luciano ; Nieto, M. Angela ; Marín, Oscar. / Molecular mechanisms controlling the migration of striatal interneurons. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 23. pp. 8718-8729.
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