Molecular mediators of hepatic steatosis and liver injury

Research output: Contribution to journalReview articlepeer-review

1557 Scopus citations

Abstract

Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides; in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse sequelae or can be associated with steatohepatitis: a condition that can result in end-stage liver disease, accounting for up to 14% of liver transplants in the US. Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of Clinical Investigation
Volume114
Issue number2
DOIs
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Medicine(all)

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