Molecular networks and the evolution of human cognitive specializations

Miles Fontenot, Genevieve Konopka

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Inroads into elucidating the origins of human cognitive specializations have taken many forms, including genetic, genomic, anatomical, and behavioral assays that typically compare humans to non-human primates. While the integration of all of these approaches is essential for ultimately understanding human cognition, here, we review the usefulness of coexpression network analysis for specifically addressing this question. An increasing number of studies have incorporated coexpression networks into brain expression studies comparing species, disease versus control tissue, brain regions, or developmental time periods. A clearer picture has emerged of the key genes driving brain evolution, as well as the developmental and regional contributions of gene expression patterns important for normal brain development and those misregulated in cognitive diseases.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume29
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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