Molecular ordering of the cell death pathway

Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases

Arul M. Chinnaiyan, Kim Orth, Karen O'Rourke, Hangjun Duan, Guy G. Poirier, Vishva M. Dixit

Research output: Contribution to journalArticle

588 Citations (Scopus)

Abstract

Genetic analyses of Caenorhabditis elegans has identified three genes that function in the regulation of nematode cell death. Mammalian homologs of two of these genes, ced-9 and ced-3, have been identified and comprise proteins belonging to the Bcl-2 and ICE families, respectively. To date, it is unclear where the negative regulators, ced-9 and bcl-2, function relative to the death effectors, ced-3 and the mammalian ced-3 homologs, respectively. Here, the molecular order of the cell death pathway is defined. Our results establish that Bcl-2 and Bcl-xL function upstream of two members of the ICE/ CED-3 family of cysteine proteases, Yama (CPP32/apopain) and ICE-LAPS (Mch3).

Original languageEnglish (US)
Pages (from-to)4573-4576
Number of pages4
JournalJournal of Biological Chemistry
Volume271
Issue number9
StatePublished - Mar 1 1996

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Cell death
Peptide Hydrolases
Cell Death
Cysteine Proteases
Caenorhabditis elegans
Genes
Caspase 3
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Molecular ordering of the cell death pathway : Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases. / Chinnaiyan, Arul M.; Orth, Kim; O'Rourke, Karen; Duan, Hangjun; Poirier, Guy G.; Dixit, Vishva M.

In: Journal of Biological Chemistry, Vol. 271, No. 9, 01.03.1996, p. 4573-4576.

Research output: Contribution to journalArticle

Chinnaiyan, Arul M. ; Orth, Kim ; O'Rourke, Karen ; Duan, Hangjun ; Poirier, Guy G. ; Dixit, Vishva M. / Molecular ordering of the cell death pathway : Bcl-2 and Bcl-xL function upstream of the ced-3-like apoptotic proteases. In: Journal of Biological Chemistry. 1996 ; Vol. 271, No. 9. pp. 4573-4576.
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