TY - JOUR
T1 - Molecular pathogenesis of lung cancer
AU - Zöchbauer-Müller, Sabine
AU - Gazdar, Adi F.
AU - Minna, John D.
PY - 2002
Y1 - 2002
N2 - Lung cancer is the most common cause of cancer death in the United States, killing more than 156,000 people every year. In the past two decades, significant progress has been made in understanding the molecular and cellular pathogenesis of lung cancer. Abnormalities of proto-oncogenes, genetic and epigenetic changes of tumor suppressor genes, the role of angiogenesis in the multistage development of lung cancer, as well as detection of molecular abnormalities in preinvasive respiratory lesions, have recently come into focus. Efforts are ongoing to translate these findings into new clinical strategies for risk assessment, chemoprevention, early diagnosis, treatment selection, and prognosis and to provide new targets and methods of treatment for lung cancer patients. All these strategies should aid in reducing the number of newly diagnosed lung cancer cases and in increasing the survival and quality of life of patients with lung cancer.
AB - Lung cancer is the most common cause of cancer death in the United States, killing more than 156,000 people every year. In the past two decades, significant progress has been made in understanding the molecular and cellular pathogenesis of lung cancer. Abnormalities of proto-oncogenes, genetic and epigenetic changes of tumor suppressor genes, the role of angiogenesis in the multistage development of lung cancer, as well as detection of molecular abnormalities in preinvasive respiratory lesions, have recently come into focus. Efforts are ongoing to translate these findings into new clinical strategies for risk assessment, chemoprevention, early diagnosis, treatment selection, and prognosis and to provide new targets and methods of treatment for lung cancer patients. All these strategies should aid in reducing the number of newly diagnosed lung cancer cases and in increasing the survival and quality of life of patients with lung cancer.
KW - Allele loss
KW - Angiogenesis
KW - Methylation
KW - Preneoplasia
KW - Tumor suppressor gene
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U2 - 10.1146/annurev.physiol.64.081501.155828
DO - 10.1146/annurev.physiol.64.081501.155828
M3 - Review article
C2 - 11826285
AN - SCOPUS:0036194329
SN - 0066-4278
VL - 64
SP - 681
EP - 708
JO - Annual review of physiology
JF - Annual review of physiology
ER -