Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40

Adi F. Gazdar, Michele Carbone

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Malignant mesothelioma is a relatively rare tumor, but the incidence of the disease appears to be increasing. Unique molecular changes are associated with the disease that distinguish it from lung cancers. Smoking is not an etiologic factor; the major causative agent is asbestos exposure, usually many years or decades before the development of the tumor. Recently, a simian virus, SV40, has been associated with malignant mesotheliomas and is a probable cofactor in tumor development. The molecular changes caused by each of these major etiologic factors and their interrelationships are the focus of this review.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalClinical lung cancer
Volume5
Issue number3
DOIs
StatePublished - Nov 2003

Keywords

  • Apoptosis
  • Asbestos
  • Carcinogenicity
  • SV40

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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