Molecular pathways controlling heart development

Eric N. Olson, Deepak Srivastava

Research output: Contribution to journalArticle

358 Scopus citations

Abstract

Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalScience
Volume272
Issue number5262
DOIs
StatePublished - May 3 1996

ASJC Scopus subject areas

  • General

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