Molecular photoacoustic tomography with colloidal nanobeacons

Dipanjan Pan; Manojit Pramanik; Angana Senpan; Xinmai Yang; Kwang H. Song; Mike J. Scott; Huiying Zhang; Patrick J. Gaffney; Samuel A. Wickline; Lihong V. Wang; Gregory M. Lanza

doi:10.1002/anie.200805947

Molecular photoacoustic tomography with colloidal nanobeacons

Dipanjan Pan, Manojit Pramanik, Angana Senpan, Xinmai Yang, Kwang H. Song, Mike J. Scott, Huiying Zhang, Patrick J. Gaffney, Samuel A. Wickline, Lihong V. Wang, Gregory M. Lanza

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

Original language	English (US)
Pages (from-to)	4170-4173
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	23
DOIs	https://doi.org/10.1002/anie.200805947
State	Published - May 25 2009

Keywords

Contrast agents
Gold
Molecular imaging
Nanoparticles
Photoacoustic tomography

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200805947

Cite this

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title = "Molecular photoacoustic tomography with colloidal nanobeacons",

abstract = "Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.",

keywords = "Contrast agents, Gold, Molecular imaging, Nanoparticles, Photoacoustic tomography",

author = "Dipanjan Pan and Manojit Pramanik and Angana Senpan and Xinmai Yang and Song, {Kwang H.} and Scott, {Mike J.} and Huiying Zhang and Gaffney, {Patrick J.} and Wickline, {Samuel A.} and Wang, {Lihong V.} and Lanza, {Gregory M.}",

year = "2009",

month = may,

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doi = "10.1002/anie.200805947",

language = "English (US)",

volume = "48",

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journal = "Angewandte Chemie - International Edition",

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T1 - Molecular photoacoustic tomography with colloidal nanobeacons

AU - Pan, Dipanjan

AU - Pramanik, Manojit

AU - Senpan, Angana

AU - Yang, Xinmai

AU - Song, Kwang H.

AU - Scott, Mike J.

AU - Zhang, Huiying

AU - Gaffney, Patrick J.

AU - Wickline, Samuel A.

AU - Wang, Lihong V.

AU - Lanza, Gregory M.

PY - 2009/5/25

Y1 - 2009/5/25

N2 - Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

AB - Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

KW - Contrast agents

KW - Gold

KW - Molecular imaging

KW - Nanoparticles

KW - Photoacoustic tomography

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Molecular photoacoustic tomography with colloidal nanobeacons

Abstract

Keywords

ASJC Scopus subject areas

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