Molecular prognostic prediction in liver cirrhosis

Nicolas Goossens, Shigeki Nakagawa, Yujin Hoshida

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The natural history of cirrhosis varies and therefore prognostic prediction is critical given the sizable patient population. A variety of clinical prognostic indicators have been developed and enable patient risk stratification although their performance is somewhat limited especially within relatively earlier stage of disease. Molecular prognostic indicators are expected to refine the prediction, and potentially link a subset of patients with molecular targeted interventions that counteract poor prognosis. Here we overview clinical and molecular prognostic indicators in the literature, and discuss critical issues to successfully define, evaluate, and deploy prognostic indicators as clinical scores or tests. The use of liver biopsy has been diminishing due to sampling variability on fibrosis assessment and emergence of imaging-or lab testbased fibrosis assessment methods. However, recent rapid developments of genomics technologies and selective molecular targeted agents has highlighted the need for biopsy tissue specimen to explore and establish molecular information-guided personalized/stratified clinical care, and eventually achieve precision medicine.

Original languageEnglish (US)
Pages (from-to)10262-10273
Number of pages12
JournalWorld Journal of Gastroenterology
Volume21
Issue number36
DOIs
Publication statusPublished - Sep 28 2015
Externally publishedYes

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Keywords

  • Biomarker
  • Cirrhosis
  • Gene expression
  • Hepatocellular carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Gastroenterology

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