Molecular regulation of kidney development: Is the answer blowing in the Wnt?

Calli E. Merkel, Courtney M. Karner, Thomas J. Carroll

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.

Original languageEnglish (US)
Pages (from-to)1825-1838
Number of pages14
JournalPediatric Nephrology
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2007

Keywords

  • Metanephros
  • Renal vesicle
  • Ureteric bud
  • β-Catenin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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