Molecular surface tailoring of biomaterials via pulsed rf plasma discharges

V. Panchalingam, Bryan Poon, Hsiao Hwei Huo, Charles R. Savage, Richard B. Timmons, Robert C. Eberhart

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A pulsed RF plasma glow discharge is employed to demonstrate molecular level controllability of surface film deposits. Molecular composition of plasma deposited films is shown to vary in a signifi-cant manner with the RF duty cycle. Three fluorocarbon monomers are used to illustrate the process. All three exhibit a trend towards increased surface CF2 content with decreasing pulsed RF duty cycle, including exclusion of oxygen. Significant variations in carbon-fluorine surface functionalities are obtained over a controllable range of film thickness. Film growth rate measurements reveal the occurrence of surface reactions during significant portions of the off portion of the duty cycle. Albumin adsorption on fluorocarbon-treated PET films is unchanged from PET controls for a 100-fold range of bulk concentrations and 60-fold range of adsorption times. However, increased retention of albumin is observed following incubation with protein-denaturing sodium dodecyl sulfate solution, the retention decreasing with increasing bulk concentration of albumin. The increased retention of albumin suggests the treated surfaces may have promise as biocompatible materials.

Original languageEnglish (US)
Pages (from-to)131-145
Number of pages15
JournalJournal of Biomaterials Science, Polymer Edition
Volume5
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Biocompatible Materials
Biomaterials
Albumins
Plasmas
Fluorocarbons
Adsorption
Fluorine
Surface reactions
Glow discharges
Sodium dodecyl sulfate
Film growth
Controllability
Sodium Dodecyl Sulfate
Film thickness
Carbon
Deposits
Monomers
Oxygen
Proteins
Growth

Keywords

  • surface modifications
  • Albumin binding
  • Fluorocarbons
  • Pulsed plasma

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials

Cite this

Panchalingam, V., Poon, B., Huo, H. H., Savage, C. R., Timmons, R. B., & Eberhart, R. C. (1994). Molecular surface tailoring of biomaterials via pulsed rf plasma discharges. Journal of Biomaterials Science, Polymer Edition, 5(1-2), 131-145. https://doi.org/10.1163/156856294X00707

Molecular surface tailoring of biomaterials via pulsed rf plasma discharges. / Panchalingam, V.; Poon, Bryan; Huo, Hsiao Hwei; Savage, Charles R.; Timmons, Richard B.; Eberhart, Robert C.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 5, No. 1-2, 01.01.1994, p. 131-145.

Research output: Contribution to journalArticle

Panchalingam, V, Poon, B, Huo, HH, Savage, CR, Timmons, RB & Eberhart, RC 1994, 'Molecular surface tailoring of biomaterials via pulsed rf plasma discharges', Journal of Biomaterials Science, Polymer Edition, vol. 5, no. 1-2, pp. 131-145. https://doi.org/10.1163/156856294X00707
Panchalingam, V. ; Poon, Bryan ; Huo, Hsiao Hwei ; Savage, Charles R. ; Timmons, Richard B. ; Eberhart, Robert C. / Molecular surface tailoring of biomaterials via pulsed rf plasma discharges. In: Journal of Biomaterials Science, Polymer Edition. 1994 ; Vol. 5, No. 1-2. pp. 131-145.
@article{1cde244788fe48db951cd4e21ece6010,
title = "Molecular surface tailoring of biomaterials via pulsed rf plasma discharges",
abstract = "A pulsed RF plasma glow discharge is employed to demonstrate molecular level controllability of surface film deposits. Molecular composition of plasma deposited films is shown to vary in a signifi-cant manner with the RF duty cycle. Three fluorocarbon monomers are used to illustrate the process. All three exhibit a trend towards increased surface CF2 content with decreasing pulsed RF duty cycle, including exclusion of oxygen. Significant variations in carbon-fluorine surface functionalities are obtained over a controllable range of film thickness. Film growth rate measurements reveal the occurrence of surface reactions during significant portions of the off portion of the duty cycle. Albumin adsorption on fluorocarbon-treated PET films is unchanged from PET controls for a 100-fold range of bulk concentrations and 60-fold range of adsorption times. However, increased retention of albumin is observed following incubation with protein-denaturing sodium dodecyl sulfate solution, the retention decreasing with increasing bulk concentration of albumin. The increased retention of albumin suggests the treated surfaces may have promise as biocompatible materials.",
keywords = "surface modifications, Albumin binding, Fluorocarbons, Pulsed plasma",
author = "V. Panchalingam and Bryan Poon and Huo, {Hsiao Hwei} and Savage, {Charles R.} and Timmons, {Richard B.} and Eberhart, {Robert C.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1163/156856294X00707",
language = "English (US)",
volume = "5",
pages = "131--145",
journal = "Journal of Biomaterials Science, Polymer Edition",
issn = "0920-5063",
publisher = "Taylor and Francis Ltd.",
number = "1-2",

}

TY - JOUR

T1 - Molecular surface tailoring of biomaterials via pulsed rf plasma discharges

AU - Panchalingam, V.

AU - Poon, Bryan

AU - Huo, Hsiao Hwei

AU - Savage, Charles R.

AU - Timmons, Richard B.

AU - Eberhart, Robert C.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A pulsed RF plasma glow discharge is employed to demonstrate molecular level controllability of surface film deposits. Molecular composition of plasma deposited films is shown to vary in a signifi-cant manner with the RF duty cycle. Three fluorocarbon monomers are used to illustrate the process. All three exhibit a trend towards increased surface CF2 content with decreasing pulsed RF duty cycle, including exclusion of oxygen. Significant variations in carbon-fluorine surface functionalities are obtained over a controllable range of film thickness. Film growth rate measurements reveal the occurrence of surface reactions during significant portions of the off portion of the duty cycle. Albumin adsorption on fluorocarbon-treated PET films is unchanged from PET controls for a 100-fold range of bulk concentrations and 60-fold range of adsorption times. However, increased retention of albumin is observed following incubation with protein-denaturing sodium dodecyl sulfate solution, the retention decreasing with increasing bulk concentration of albumin. The increased retention of albumin suggests the treated surfaces may have promise as biocompatible materials.

AB - A pulsed RF plasma glow discharge is employed to demonstrate molecular level controllability of surface film deposits. Molecular composition of plasma deposited films is shown to vary in a signifi-cant manner with the RF duty cycle. Three fluorocarbon monomers are used to illustrate the process. All three exhibit a trend towards increased surface CF2 content with decreasing pulsed RF duty cycle, including exclusion of oxygen. Significant variations in carbon-fluorine surface functionalities are obtained over a controllable range of film thickness. Film growth rate measurements reveal the occurrence of surface reactions during significant portions of the off portion of the duty cycle. Albumin adsorption on fluorocarbon-treated PET films is unchanged from PET controls for a 100-fold range of bulk concentrations and 60-fold range of adsorption times. However, increased retention of albumin is observed following incubation with protein-denaturing sodium dodecyl sulfate solution, the retention decreasing with increasing bulk concentration of albumin. The increased retention of albumin suggests the treated surfaces may have promise as biocompatible materials.

KW - surface modifications

KW - Albumin binding

KW - Fluorocarbons

KW - Pulsed plasma

UR - http://www.scopus.com/inward/record.url?scp=84904470077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904470077&partnerID=8YFLogxK

U2 - 10.1163/156856294X00707

DO - 10.1163/156856294X00707

M3 - Article

VL - 5

SP - 131

EP - 145

JO - Journal of Biomaterials Science, Polymer Edition

JF - Journal of Biomaterials Science, Polymer Edition

SN - 0920-5063

IS - 1-2

ER -