Molecular targets for cancer therapy and prevention

Adi F. Gazdar, Kuniharu Miyajima, Jyotsna Reddy, Ubaradka G. Sathyanarayana, Hisayuki Shigematsu, Makoto Suzuki, Takao Takahashi, Narayan Shivapurkar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Despite major improvements in patient management, the prognosis for patients with lung cancer remains dismal. As our knowledge of the molecular biology of cancers has increased, new targets for therapeutic interventions have been identified. In this article, we discuss some of the more recent developments in this field. They include revisiting some of the established concepts, such as retinoid metabolism and the inhibition of cyclooxygenase-2 metabolism. In addition, newer targets, such as transforming growth factor-β signaling, Janus-activated kinase/signal transducers and activators of transcription pathway, and cell invasion are discussed. These studies demonstrate that multiple, often overlapping, mechanisms of disruption are present in lung cancer cells, presenting a plethora of molecular targets.

Original languageEnglish (US)
JournalChest
Volume125
Issue number5 SUPPL.
StatePublished - May 2004

Fingerprint

Lung Neoplasms
Janus Kinases
Retinoids
Transforming Growth Factors
Cyclooxygenase 2
Transducers
Molecular Biology
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Gazdar, A. F., Miyajima, K., Reddy, J., Sathyanarayana, U. G., Shigematsu, H., Suzuki, M., ... Shivapurkar, N. (2004). Molecular targets for cancer therapy and prevention. Chest, 125(5 SUPPL.).

Molecular targets for cancer therapy and prevention. / Gazdar, Adi F.; Miyajima, Kuniharu; Reddy, Jyotsna; Sathyanarayana, Ubaradka G.; Shigematsu, Hisayuki; Suzuki, Makoto; Takahashi, Takao; Shivapurkar, Narayan.

In: Chest, Vol. 125, No. 5 SUPPL., 05.2004.

Research output: Contribution to journalArticle

Gazdar, AF, Miyajima, K, Reddy, J, Sathyanarayana, UG, Shigematsu, H, Suzuki, M, Takahashi, T & Shivapurkar, N 2004, 'Molecular targets for cancer therapy and prevention', Chest, vol. 125, no. 5 SUPPL..
Gazdar AF, Miyajima K, Reddy J, Sathyanarayana UG, Shigematsu H, Suzuki M et al. Molecular targets for cancer therapy and prevention. Chest. 2004 May;125(5 SUPPL.).
Gazdar, Adi F. ; Miyajima, Kuniharu ; Reddy, Jyotsna ; Sathyanarayana, Ubaradka G. ; Shigematsu, Hisayuki ; Suzuki, Makoto ; Takahashi, Takao ; Shivapurkar, Narayan. / Molecular targets for cancer therapy and prevention. In: Chest. 2004 ; Vol. 125, No. 5 SUPPL.
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