TY - JOUR
T1 - Molecular targets for cancer therapy and prevention
AU - Gazdar, Adi F.
AU - Miyajima, Kuniharu
AU - Reddy, Jyotsna
AU - Sathyanarayana, Ubaradka G.
AU - Shigematsu, Hisayuki
AU - Suzuki, Makoto
AU - Takahashi, Takao
AU - Shivapurkar, Narayan
PY - 2004/5
Y1 - 2004/5
N2 - Despite major improvements in patient management, the prognosis for patients with lung cancer remains dismal. As our knowledge of the molecular biology of cancers has increased, new targets for therapeutic interventions have been identified. In this article, we discuss some of the more recent developments in this field. They include revisiting some of the established concepts, such as retinoid metabolism and the inhibition of cyclooxygenase-2 metabolism. In addition, newer targets, such as transforming growth factor-β signaling, Janus-activated kinase/signal transducers and activators of transcription pathway, and cell invasion are discussed. These studies demonstrate that multiple, often overlapping, mechanisms of disruption are present in lung cancer cells, presenting a plethora of molecular targets.
AB - Despite major improvements in patient management, the prognosis for patients with lung cancer remains dismal. As our knowledge of the molecular biology of cancers has increased, new targets for therapeutic interventions have been identified. In this article, we discuss some of the more recent developments in this field. They include revisiting some of the established concepts, such as retinoid metabolism and the inhibition of cyclooxygenase-2 metabolism. In addition, newer targets, such as transforming growth factor-β signaling, Janus-activated kinase/signal transducers and activators of transcription pathway, and cell invasion are discussed. These studies demonstrate that multiple, often overlapping, mechanisms of disruption are present in lung cancer cells, presenting a plethora of molecular targets.
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U2 - 10.1378/chest.125.5_suppl.97S-a
DO - 10.1378/chest.125.5_suppl.97S-a
M3 - Article
C2 - 15136434
AN - SCOPUS:2442597820
SN - 0012-3692
VL - 125
SP - 97S-101S
JO - CHEST
JF - CHEST
IS - 5 SUPPL.
ER -