Molecular targets for cancer therapy and prevention

Adi F. Gazdar, Kuniharu Miyajima, Jyotsna Reddy, Ubaradka G. Sathyanarayana, Hisayuki Shigematsu, Makoto Suzuki, Takao Takahashi, Narayan Shivapurkar

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Despite major improvements in patient management, the prognosis for patients with lung cancer remains dismal. As our knowledge of the molecular biology of cancers has increased, new targets for therapeutic interventions have been identified. In this article, we discuss some of the more recent developments in this field. They include revisiting some of the established concepts, such as retinoid metabolism and the inhibition of cyclooxygenase-2 metabolism. In addition, newer targets, such as transforming growth factor-β signaling, Janus-activated kinase/signal transducers and activators of transcription pathway, and cell invasion are discussed. These studies demonstrate that multiple, often overlapping, mechanisms of disruption are present in lung cancer cells, presenting a plethora of molecular targets.

Original languageEnglish (US)
Pages (from-to)97S-101S
JournalCHEST
Volume125
Issue number5 SUPPL.
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Gazdar, A. F., Miyajima, K., Reddy, J., Sathyanarayana, U. G., Shigematsu, H., Suzuki, M., Takahashi, T., & Shivapurkar, N. (2004). Molecular targets for cancer therapy and prevention. CHEST, 125(5 SUPPL.), 97S-101S. https://doi.org/10.1378/chest.125.5_suppl.97S-a