Monitoring for compartmental syndrome using near-infrared spectroscopy: A noninvasive, continuous, transcutaneous monitoring technique

Jeff L. Garr, Larry M. Gentilello, Peter A. Cole, Charles N. Mock, Frederick A. Matsen

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: The diagnosis of compartmental syndrome (CS) may be delayed because current monitoring techniques are invasive and intermittent and the compartment pressure (CP) that predicts ischemia is variable. Fiber-optic devices using near-infrared (NIR) wavelength reflection can determine the redox state of light-absorbing molecules and have been used to monitor venous hemoglobin saturation to detect ischemia during low-flow states. The purpose of this study was to determine if NIR spectroscopy can provide continuous, transcutaneous, noninvasive monitoring for muscle ischemia in an animal model of CS. Methods: Nine swine were anesthetized and a 20-mm NIR probe was placed over the anterolateral compartment of the hind leg to provide continuous determination of muscle oxyhemoglobin level. Needles were inserted into the compartment to measure CP. A nerve stimulator was placed over the peroneal nerve to induce dorsiflexion twitch. Albumin was infused into the muscle to incrementally increase CP until there was complete loss of dorsiflexion, then after 20 minutes fasciotomy was performed. Results: All animals lost dorsiflexion at CP of 43 ± 14 mm Hg. There was a significant inverse correlation between CP and oxyhemoglobin level (r = -0.78; p < 0.001) and a correlation between oxyhemoglobin and perfusion pressure (mean arterial pressure minus CP) (r = 0.66; p < 0.001). Redox state was a more consistent predictor of twitch loss than perfusion pressure. Conclusion: Muscle oxyhemoglobin level measured by NIR spectroscopy strongly reflected CP, perfusion pressure, and loss of dorsiflexion twitch. Currently available portable NIR devices may provide the benefit of continuous, noninvasive monitoring for CS. Further studies to determine the role of this technology in the detection of compartmental syndrome are warranted.

Original languageEnglish (US)
Pages (from-to)613-618
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume46
Issue number4
StatePublished - Apr 1999

Fingerprint

Near-Infrared Spectroscopy
Pressure
Oxyhemoglobins
Muscles
Ischemia
Perfusion
Oxidation-Reduction
Equipment and Supplies
Peroneal Nerve
Needles
Albumins
Leg
Arterial Pressure
Hemoglobins
Swine
Animal Models
Technology
Light

Keywords

  • Compartmental syndromes
  • Fractures
  • Near-infrared spectroscopy
  • Orthopedics
  • Oximetry
  • Traumatology

ASJC Scopus subject areas

  • Surgery

Cite this

Monitoring for compartmental syndrome using near-infrared spectroscopy : A noninvasive, continuous, transcutaneous monitoring technique. / Garr, Jeff L.; Gentilello, Larry M.; Cole, Peter A.; Mock, Charles N.; Matsen, Frederick A.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 46, No. 4, 04.1999, p. 613-618.

Research output: Contribution to journalArticle

Garr, Jeff L. ; Gentilello, Larry M. ; Cole, Peter A. ; Mock, Charles N. ; Matsen, Frederick A. / Monitoring for compartmental syndrome using near-infrared spectroscopy : A noninvasive, continuous, transcutaneous monitoring technique. In: Journal of Trauma - Injury, Infection and Critical Care. 1999 ; Vol. 46, No. 4. pp. 613-618.
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