Monitoring physiological function by detection of exogenous fluorescent contrast agents

Richard B. Dorshow, Joseph E. Bugaj, Samuel Achilefu, Raghavan Rajagopalan, Arthur H. Combs

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non-invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Optical Diagnostics of Biological Fluids IV - San Jose, CA, USA
Duration: Jan 26 1999Jan 27 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Monitoring physiological function by detection of exogenous fluorescent contrast agents'. Together they form a unique fingerprint.

Cite this