TY - GEN
T1 - Monte Carlo simulation based scatter correction in 3D list-mode image reconstruction
AU - Lou, Kai
AU - Sun, Xishan
AU - Clark, John
AU - Shao, Yiping
N1 - Funding Information:
This research was supported partially by the Cancer Prevention and Research Institute of Texas grant No. RP120326.
Publisher Copyright:
© 2014 IEEE.
PY - 2016/3/10
Y1 - 2016/3/10
N2 - We developed a Monte Carlo simulation based scatter correction method for 3D list-mode image reconstruction, and tested the method with Monte Carlo simulations. First, an emission image without scatter correction was reconstructed using MLEM. A transmission image was generated with the CT image. Then, based on the emission and transmission images, GATE was used to simulate coincidence events with their line-of responses (LORs) grouped according to their spatial positions (e.g. interaction positions or detector modules). The scatter ratio (scatter vs total coincidences) in each LOR group was calculated and stored in a scatter table. Finally, the scatter table was applied in a new image reconstruction to correct the scatter on the basis of each LOR group. The method was implemented in a simulated brain-size PET, with 300×300×100 mm3 FOV, 2×2×30 mm3 LYSO crystals, and 5 mm depth-of-interaction (DOI) resolution. Images of a 150×150×80 mm3 PMMA phantom inserted with three different radioisotope distributions were studied, including a point source array, a hot rod matrix, and a uniform source. We used detector module as the criteria to group LORs. With scatter correction, image resolution was almost the same as measured by point sources at different FOV positions; hot-rod sources showed visually improved image quality with reduced background noise; image SNR of the uniform source was not impacted. This method has been successfully implemented in the brain-size PET with improved image quality. It can be potentially applied to other list-mode 3D PET systems, with considering the accuracy and variation of scatter ratio in LOR grouping.
AB - We developed a Monte Carlo simulation based scatter correction method for 3D list-mode image reconstruction, and tested the method with Monte Carlo simulations. First, an emission image without scatter correction was reconstructed using MLEM. A transmission image was generated with the CT image. Then, based on the emission and transmission images, GATE was used to simulate coincidence events with their line-of responses (LORs) grouped according to their spatial positions (e.g. interaction positions or detector modules). The scatter ratio (scatter vs total coincidences) in each LOR group was calculated and stored in a scatter table. Finally, the scatter table was applied in a new image reconstruction to correct the scatter on the basis of each LOR group. The method was implemented in a simulated brain-size PET, with 300×300×100 mm3 FOV, 2×2×30 mm3 LYSO crystals, and 5 mm depth-of-interaction (DOI) resolution. Images of a 150×150×80 mm3 PMMA phantom inserted with three different radioisotope distributions were studied, including a point source array, a hot rod matrix, and a uniform source. We used detector module as the criteria to group LORs. With scatter correction, image resolution was almost the same as measured by point sources at different FOV positions; hot-rod sources showed visually improved image quality with reduced background noise; image SNR of the uniform source was not impacted. This method has been successfully implemented in the brain-size PET with improved image quality. It can be potentially applied to other list-mode 3D PET systems, with considering the accuracy and variation of scatter ratio in LOR grouping.
UR - http://www.scopus.com/inward/record.url?scp=84965021902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965021902&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2014.7430791
DO - 10.1109/NSSMIC.2014.7430791
M3 - Conference contribution
AN - SCOPUS:84965021902
T3 - 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
BT - 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Y2 - 8 November 2014 through 15 November 2014
ER -