Mood and cognitive changes during systemic corticosteroid therapy

E. Sherwood Brown, Patricia A. Chandler

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Background: Physicians in the United States write approximately 10 million new prescriptions for oral corticosteroids each year. Common side effects of corticosteroids include weight gain, osteoporosis, and diabetes mellitus. This article reviews the available literature on psychiatric and cognitive changes during corticosteroid therapy. Method: A search of the MEDLINE and psycINFO databases was conducted to find clinically relevant articles on psychiatric and cognitive side effects with corticosteroids using search terms including corticosteroid, prednisone, mania, depression, psychosis, mood, memory, and cognition. Results: Symptoms of hypomania, mania, depression, and psychosis occur during corticosteroid therapy as do cognitive changes, particularly deficits in verbal or declarative memory. Psychiatric symptoms appear to be dose-dependent and generally occur during the first few weeks of therapy. Patients who must remain on corticosteroids may benefit from pharmacotherapeutic approaches, such as lithium and the new antipsychotic medications. Conclusion: Mood and cognitive changes with corticosteroids appear to be common but generally mild and reversible side effects. More studies are needed to determine effective treatment for steroid-induced psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Psychiatry and Mental health

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