TY - JOUR
T1 - More than Cholesterol Transporters
T2 - Lipoprotein Receptors in CNS Function and Neurodegeneration
AU - Lane-Donovan, Courtney
AU - Philips, Gary T.
AU - Herz, Joachim
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health, Lupe Murchison Foundation, Ted Nash Longlife Foundation, Consortium for Frontotemporal Dementia Research, Alexander von Humboldt Stiftung, and Brightfocus Foundation. Additionally, we would like to thank Theresa Pohlkamp and Catherine Wasser for their thoughtful reading of manuscript drafts. We thank Nancy Heard and Barbara Dacus for their excellent help with the artwork.
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adultbrain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction. The low-density lipoprotein receptors have diverse biological functions that transcend lipid metabolism. Lane-Donovan, Philips, and Herz review current understanding of lipoprotein receptor function in the CNS and AD pathology, with an emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
AB - Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adultbrain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction. The low-density lipoprotein receptors have diverse biological functions that transcend lipid metabolism. Lane-Donovan, Philips, and Herz review current understanding of lipoprotein receptor function in the CNS and AD pathology, with an emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
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U2 - 10.1016/j.neuron.2014.08.005
DO - 10.1016/j.neuron.2014.08.005
M3 - Review article
C2 - 25144875
AN - SCOPUS:84907364703
SN - 0896-6273
VL - 83
SP - 771
EP - 787
JO - Neuron
JF - Neuron
IS - 4
ER -