More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

Courtney Lane-Donovan, Gary T. Philips, Joachim Herz

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adultbrain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction. The low-density lipoprotein receptors have diverse biological functions that transcend lipid metabolism. Lane-Donovan, Philips, and Herz review current understanding of lipoprotein receptor function in the CNS and AD pathology, with an emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.

Original languageEnglish (US)
Pages (from-to)771-787
Number of pages17
JournalNeuron
Volume83
Issue number4
DOIs
StatePublished - Aug 20 2014

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Lipoprotein Receptors
Alzheimer Disease
LDL Receptors
Central Nervous System Diseases
Cholesterol
Endocytosis
Lipid Metabolism
Amyloid
Pathology
Synapses
Signal Transduction
Genes
Transcend

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

More than Cholesterol Transporters : Lipoprotein Receptors in CNS Function and Neurodegeneration. / Lane-Donovan, Courtney; Philips, Gary T.; Herz, Joachim.

In: Neuron, Vol. 83, No. 4, 20.08.2014, p. 771-787.

Research output: Contribution to journalArticle

Lane-Donovan, Courtney ; Philips, Gary T. ; Herz, Joachim. / More than Cholesterol Transporters : Lipoprotein Receptors in CNS Function and Neurodegeneration. In: Neuron. 2014 ; Vol. 83, No. 4. pp. 771-787.
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