TY - JOUR
T1 - Morphea patients with mucocutaneous involvement
T2 - A cross-sectional study from the Morphea in Adults and Children (MAC) cohort
AU - Prasad, Smriti
AU - Black, Samantha M.
AU - Zhu, Jane L.
AU - Sharma, Shivani
AU - Jacobe, Heidi
N1 - Publisher Copyright:
© 2020
PY - 2021/7
Y1 - 2021/7
N2 - Background: Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized, to our knowledge. Objective: To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions who were enrolled in the Morphea in Adults and Children cohort. Methods: Cross-sectional study of 735 patients in the Morphea in Adults and Children cohort from 2007 to 2018. Results: A total of 4.6% of linear morphea patients had oral involvement versus 2.4% among the entire cohort, whereas 10.3% of generalized morphea patients had genital involvement versus 3.7% among the entire cohort. Patients with genital lesions were older at disease onset than those with oral morphea (57 versus 11.5 years; P <.001) and had more frequent extragenital lichen sclerosus et atrophicus (59.2% versus 5.6%; P =.004). Limitations: Selection bias and limited number of affected subjects. Conclusion: Oral morphea lesions predominate in younger patients with facial linear morphea, whereas genital lesions predominate in postmenopausal women with overlying extragenital lichen sclerosus et atrophicus.
AB - Background: Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized, to our knowledge. Objective: To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions who were enrolled in the Morphea in Adults and Children cohort. Methods: Cross-sectional study of 735 patients in the Morphea in Adults and Children cohort from 2007 to 2018. Results: A total of 4.6% of linear morphea patients had oral involvement versus 2.4% among the entire cohort, whereas 10.3% of generalized morphea patients had genital involvement versus 3.7% among the entire cohort. Patients with genital lesions were older at disease onset than those with oral morphea (57 versus 11.5 years; P <.001) and had more frequent extragenital lichen sclerosus et atrophicus (59.2% versus 5.6%; P =.004). Limitations: Selection bias and limited number of affected subjects. Conclusion: Oral morphea lesions predominate in younger patients with facial linear morphea, whereas genital lesions predominate in postmenopausal women with overlying extragenital lichen sclerosus et atrophicus.
KW - Localized Scleroderma Activity Index
KW - Localized Scleroderma Damage Index
KW - Physician Global Assessment of Disease Activity
KW - Physician Global Assessment of Disease Damage
KW - lichen sclerosus atrophicus
KW - localized scleroderma
KW - morphea
KW - mucocutaneous morphea
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U2 - 10.1016/j.jaad.2020.10.093
DO - 10.1016/j.jaad.2020.10.093
M3 - Article
C2 - 33249064
AN - SCOPUS:85106558446
SN - 0190-9622
VL - 85
SP - 114
EP - 120
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -