Morphine and β-endorphin influence the secretion of the endocrine pancreas [18]

E. Ipp; R. Dobbs; Roger H Unger

doi:10.1038/276190a0

Morphine and β-endorphin influence the secretion of the endocrine pancreas [18]

E. Ipp, R. Dobbs, Roger H Unger

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Abstract

OPIOID PEPTIDES^1-3 are present in high concentrations in those areas of the brain and gastrointestinal tract⁴ in which opiate receptors⁵ are numerous and a biological response to opiates well established⁶. The report of immunoreactive enkephalin in the pancreas⁴ raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.

Original language	English (US)
Pages (from-to)	190-191
Number of pages	2
Journal	Nature
Volume	276
Issue number	5684
DOIs	https://doi.org/10.1038/276190a0
State	Published - Dec 1 1978

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title = "Morphine and β-endorphin influence the secretion of the endocrine pancreas [18]",

abstract = "OPIOID PEPTIDES1-3 are present in high concentrations in those areas of the brain and gastrointestinal tract4 in which opiate receptors5 are numerous and a biological response to opiates well established6. The report of immunoreactive enkephalin in the pancreas4 raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.",

author = "E. Ipp and R. Dobbs and Unger, {Roger H}",

year = "1978",

month = dec,

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doi = "10.1038/276190a0",

language = "English (US)",

volume = "276",

pages = "190--191",

journal = "Nature",

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T1 - Morphine and β-endorphin influence the secretion of the endocrine pancreas [18]

AU - Ipp, E.

AU - Dobbs, R.

AU - Unger, Roger H

PY - 1978/12/1

Y1 - 1978/12/1

N2 - OPIOID PEPTIDES1-3 are present in high concentrations in those areas of the brain and gastrointestinal tract4 in which opiate receptors5 are numerous and a biological response to opiates well established6. The report of immunoreactive enkephalin in the pancreas4 raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.

AB - OPIOID PEPTIDES1-3 are present in high concentrations in those areas of the brain and gastrointestinal tract4 in which opiate receptors5 are numerous and a biological response to opiates well established6. The report of immunoreactive enkephalin in the pancreas4 raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.

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U2 - 10.1038/276190a0

DO - 10.1038/276190a0

M3 - Letter

C2 - 216921

AN - SCOPUS:0018135258

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VL - 276

SP - 190

EP - 191

JO - Nature

JF - Nature

IS - 5684

ER -

Morphine and β-endorphin influence the secretion of the endocrine pancreas [18]

Abstract

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