Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons

G. A. Gudelsky, J. C. Porter

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Dopamine concentrations in pituitary stalk plasma ovariectomized rats and ovariectomized, estrogen-treated rats were measured following the subcutaneous administration of morphine or the intraventricular administration of ß-endorphin or [D-Ala2]-methionine-enkephalinamide, a synthetic enkephalin analog. The administration of morphine or the opioid peptides led to an 85-89% reduction in the concentration of dopamine in pituitary stalk plasma when compared to the mean concentration of dopamine in stalk plasma of vehicle-treated animals. Pretreatment of rats with naloxene, an opiate antagonist, prevented the opioid peptide-induced reduction in the stalk plasma concentration of dopamine. These results are supportive of the hypothesis that endogenous opioid peptides modulate the release of dopamine by tuberoinfundibular neurons into hypophysial portal blood.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalLife Sciences
Volume25
Issue number19
DOIs
StatePublished - Nov 5 1979

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Opioid Peptides
Dopaminergic Neurons
Morphine
Neurons
Dopamine
Pituitary Gland
Plasmas
Rats
Opiate Alkaloids
Endorphins
Enkephalins
Estrogens
Animals
Blood

ASJC Scopus subject areas

  • Pharmacology

Cite this

Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons. / Gudelsky, G. A.; Porter, J. C.

In: Life Sciences, Vol. 25, No. 19, 05.11.1979, p. 1697-1702.

Research output: Contribution to journalArticle

Gudelsky, G. A. ; Porter, J. C. / Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons. In: Life Sciences. 1979 ; Vol. 25, No. 19. pp. 1697-1702.
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