Morphine-induced hyperglycemia

Role of insulin and glucagon

E. Ipp, V. Schusdziarra, V. Harris, Roger H Unger

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

An iv bolus injection of 0.5 mg/kg morphine, about twice the therapeutic dose, caused plasma glucose to rise more than 120 mg/dl in alloxan-diabetic conscious dogs but had little effect on conscious normal dogs. Plasma glucagon rose in the diabetic and nondiabetic groups by 30 ± 10 and 100 ± 29 pg/ml, rescpectively, but insulin levels increased significantly only in the nondiabetics. The hyperglycemic action of morphine may, at least in part, be the result of an increase in glucagon secretion without a sufficient accompanying release of insulin.

Original languageEnglish (US)
Pages (from-to)461-463
Number of pages3
JournalEndocrinology
Volume107
Issue number2
StatePublished - 1980

Fingerprint

Glucagon
Hyperglycemia
Morphine
Dogs
Insulin
Alloxan
Glucose
Injections
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Ipp, E., Schusdziarra, V., Harris, V., & Unger, R. H. (1980). Morphine-induced hyperglycemia: Role of insulin and glucagon. Endocrinology, 107(2), 461-463.

Morphine-induced hyperglycemia : Role of insulin and glucagon. / Ipp, E.; Schusdziarra, V.; Harris, V.; Unger, Roger H.

In: Endocrinology, Vol. 107, No. 2, 1980, p. 461-463.

Research output: Contribution to journalArticle

Ipp, E, Schusdziarra, V, Harris, V & Unger, RH 1980, 'Morphine-induced hyperglycemia: Role of insulin and glucagon', Endocrinology, vol. 107, no. 2, pp. 461-463.
Ipp E, Schusdziarra V, Harris V, Unger RH. Morphine-induced hyperglycemia: Role of insulin and glucagon. Endocrinology. 1980;107(2):461-463.
Ipp, E. ; Schusdziarra, V. ; Harris, V. ; Unger, Roger H. / Morphine-induced hyperglycemia : Role of insulin and glucagon. In: Endocrinology. 1980 ; Vol. 107, No. 2. pp. 461-463.
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