@article{ebbea86714a4425daa81500a97401c63,
title = "Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability",
abstract = "The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.",
author = "Kristina Valentinova and Anna Tchenio and Massimo Trusel and Clerke, {Joseph A.} and Lalive, {Arnaud L.} and Stamatina Tzanoulinou and Alessandro Matera and Imane Moutkine and Luc Maroteaux and Paolicelli, {Rosa C.} and Andrea Volterra and Camilla Bellone and Manuel Mameli",
note = "Funding Information: The authors thank F.J. Meye and the Mameli Laboratory for comments on the manuscript. This work was supported by funds from the ERC StG SalienSy 335333 and the SNSF (31003A) to M.M. They also thank D. Szymkowski for the donation of XENP1595, and G. Kollias and H. Strubbe for the use and breeding of the Tnfr1fl/fl mouse line. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2019",
month = jul,
day = "1",
doi = "10.1038/s41593-019-0421-4",
language = "English (US)",
volume = "22",
pages = "1053--1056",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",
}