TY - JOUR
T1 - Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors
AU - Levin, Daniel L.
AU - Fixler, David E
AU - Morriss, Frances C.
AU - Tyson, Jon
N1 - Funding Information:
From The Departments of Pediatrics and Anesthesia, University of Texas Health Science Center at Dallas. Supported by University of Texas Grant 5-S01-RR-05426-14, American Heart Association Grant-in-Aid 76-878, and American Heart Association Texas' Affiliate Grant 53940. *Reprint address: Department of Pediatrics, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd., Dallas; TX 75235.
PY - 1978/3
Y1 - 1978/3
N2 - Since the effects of prostaglandin synthetase inhibitors on the developing human fetal pulmonary vasculature are unknown, we studied the lungs of two infants, one whose mother took salicylates and the other whose mother took indomethacin during pregnancy. Lungs were fixed by perfusion and fifth generation (resistance) vessels identified. The infant with chronic exposure to aspirin had premature constriction of the ductus arteriosus, tricuspid insufficiency, increased pulmonary arterial medial width/external diameter ratio due to increased smooth muscle, and a decreased number of pulmonary vessels/cm2 lung tissue. The infant with short-term exposure to indomethacin had hypoxemia, increased pulmonary arterial m/d ratio due to increased smooth muscle, and a normal number of pulmonary vessels/cm2 lung tissue. These abnormalities may be due to the effects of prostaglandin synthetase inhibitor drugs on the ductus arteriosus and/or the pulmonary vessels of the human fetus.
AB - Since the effects of prostaglandin synthetase inhibitors on the developing human fetal pulmonary vasculature are unknown, we studied the lungs of two infants, one whose mother took salicylates and the other whose mother took indomethacin during pregnancy. Lungs were fixed by perfusion and fifth generation (resistance) vessels identified. The infant with chronic exposure to aspirin had premature constriction of the ductus arteriosus, tricuspid insufficiency, increased pulmonary arterial medial width/external diameter ratio due to increased smooth muscle, and a decreased number of pulmonary vessels/cm2 lung tissue. The infant with short-term exposure to indomethacin had hypoxemia, increased pulmonary arterial m/d ratio due to increased smooth muscle, and a normal number of pulmonary vessels/cm2 lung tissue. These abnormalities may be due to the effects of prostaglandin synthetase inhibitor drugs on the ductus arteriosus and/or the pulmonary vessels of the human fetus.
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U2 - 10.1016/S0022-3476(78)80453-3
DO - 10.1016/S0022-3476(78)80453-3
M3 - Article
C2 - 416191
AN - SCOPUS:0017836041
SN - 0022-3476
VL - 92
SP - 478
EP - 483
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -