Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate

R. J. Fallon; N. K. Ghosh; R. P. Cox

Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate

R. J. Fallon, N. K. Ghosh, R. P. Cox

Research output: Contribution to journal › Article › peer-review

Abstract

HeLa cells can be induced to undergo morphologic and biosynthetic 'differentiation' by growth in medium with sodium butyrate and certain other inhibitors of DNA synthesis. Modulations of cell phenotype include development desmosomes and tonofilaments and production of several glycopeptide trophic hormones (HCG, FSH, and LH). Mediators of these effects focus the cell population at the G₁-S phase transition point.

Original language	English (US)
Pages (from-to)	129-143
Number of pages	15
Journal	Birth Defects: Original Article Series
Volume	16
Issue number	2
State	Published - 1980

ASJC Scopus subject areas

Developmental Biology
Genetics(clinical)

Cite this

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title = "Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate",

abstract = "HeLa cells can be induced to undergo morphologic and biosynthetic 'differentiation' by growth in medium with sodium butyrate and certain other inhibitors of DNA synthesis. Modulations of cell phenotype include development desmosomes and tonofilaments and production of several glycopeptide trophic hormones (HCG, FSH, and LH). Mediators of these effects focus the cell population at the G1-S phase transition point.",

author = "Fallon, {R. J.} and Ghosh, {N. K.} and Cox, {R. P.}",

year = "1980",

language = "English (US)",

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AU - Fallon, R. J.

AU - Ghosh, N. K.

AU - Cox, R. P.

PY - 1980

Y1 - 1980

N2 - HeLa cells can be induced to undergo morphologic and biosynthetic 'differentiation' by growth in medium with sodium butyrate and certain other inhibitors of DNA synthesis. Modulations of cell phenotype include development desmosomes and tonofilaments and production of several glycopeptide trophic hormones (HCG, FSH, and LH). Mediators of these effects focus the cell population at the G1-S phase transition point.

AB - HeLa cells can be induced to undergo morphologic and biosynthetic 'differentiation' by growth in medium with sodium butyrate and certain other inhibitors of DNA synthesis. Modulations of cell phenotype include development desmosomes and tonofilaments and production of several glycopeptide trophic hormones (HCG, FSH, and LH). Mediators of these effects focus the cell population at the G1-S phase transition point.

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AN - SCOPUS:0019276234

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ER -

Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate

Abstract

ASJC Scopus subject areas

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