Morphology of norepinephrine-induced acute renal failure in the dog

R. E. Bulger, T. J. Burke, R. E. Cronin, R. W. Schrier, D. C. Dobyan

Research output: Contribution to journalArticle

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Abstract

The 40-minute infusion of norepinephrine (NE) into the renal artery of dogs produces a reversible ischemic model of acute renal failure. While the physiology of this model has been extensively studied, no complete description of the pathology exists. This study uses light microscopy and transmission electron microscopy to describe and quantitate the structural and ultrastructural changes which occur in the kidneys of dogs 1, 3, and 24 hours after the intrarenal infusion of 0.75 mg/kg/minute of NE. One hour after a 40-minute NE infusion the majority of convoluted and straight proximal tubules showed apical blebs, loss of brush border, microvillar whorl formation, and mitochondrial condensation and high-amplitude swelling with flocculent densities. Necrotic cells were occasionally seen at 1 hour. The injury was progressive after 3 hours and by 24 hours animals had either complete or partial patchy necrosis of all regions of the proximal tubule. The percentages of injured and necrotic proximal tubules in outer, mid-, and inner cortical regions are presented. We conclude that the extent and pattern of injury seen after NE infusion differs significantly from the renal artery clamping model of ischemia.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalAnatomical Record
Volume214
Issue number4
StatePublished - 1986

Fingerprint

renal failure
norepinephrine
Acute Kidney Injury
proximal tubules
Norepinephrine
Dogs
dogs
kidneys
Renal Artery
arteries
pathology
swelling
physiology
condensation
transmission electron microscopy
microscopy
Wounds and Injuries
Blister
Microvilli
ischemia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Bulger, R. E., Burke, T. J., Cronin, R. E., Schrier, R. W., & Dobyan, D. C. (1986). Morphology of norepinephrine-induced acute renal failure in the dog. Anatomical Record, 214(4), 341-347.

Morphology of norepinephrine-induced acute renal failure in the dog. / Bulger, R. E.; Burke, T. J.; Cronin, R. E.; Schrier, R. W.; Dobyan, D. C.

In: Anatomical Record, Vol. 214, No. 4, 1986, p. 341-347.

Research output: Contribution to journalArticle

Bulger, RE, Burke, TJ, Cronin, RE, Schrier, RW & Dobyan, DC 1986, 'Morphology of norepinephrine-induced acute renal failure in the dog', Anatomical Record, vol. 214, no. 4, pp. 341-347.
Bulger RE, Burke TJ, Cronin RE, Schrier RW, Dobyan DC. Morphology of norepinephrine-induced acute renal failure in the dog. Anatomical Record. 1986;214(4):341-347.
Bulger, R. E. ; Burke, T. J. ; Cronin, R. E. ; Schrier, R. W. ; Dobyan, D. C. / Morphology of norepinephrine-induced acute renal failure in the dog. In: Anatomical Record. 1986 ; Vol. 214, No. 4. pp. 341-347.
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