Morphometric changes of the human midbrain with normal aging

MR and stereologic findings

P. M. Doraiswamy, C. Na, M. M. Husain, G. S. Figiel, W. M. McDonald, E. H. Ellinwood, O. B. Boyko, K. R R Krishnan

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To determine the effects of age on estimated midbrain volume. Patients and Methods: T2-weighted MR imaging and an unbiased stereologic method were used in 75 volunteers; the subjects ranged in age from 21 to 82 years and were without any significant neurologic or psychiatric disorders. Results: Age was negatively correlated with estimated midbrain volume (R = -.39, P<.0005), with the anteroposterior diameter through the substantia nigra (R = -.33, P<.004) and with the interpeduncular distance (R = -.24, P<.04). The linear measurements for the right and left side were almost identical. These findings are consistent with prior reports of nigrostriatal degeneration with increasing age. Furthermore, they suggest a close symmetry of age-related changes between the right and left side in normal subjects. Conclusion: Volumetric and linear measurements of midbrain morphology with MR may prove useful in the investigation of neurologic disorders such as Parkinson disease.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume13
Issue number1
StatePublished - 1992

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Mesencephalon
Substantia Nigra
Nervous System Diseases
Nervous System
Parkinson Disease
Psychiatry
Volunteers

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Doraiswamy, P. M., Na, C., Husain, M. M., Figiel, G. S., McDonald, W. M., Ellinwood, E. H., ... Krishnan, K. R. R. (1992). Morphometric changes of the human midbrain with normal aging: MR and stereologic findings. American Journal of Neuroradiology, 13(1), 383-386.

Morphometric changes of the human midbrain with normal aging : MR and stereologic findings. / Doraiswamy, P. M.; Na, C.; Husain, M. M.; Figiel, G. S.; McDonald, W. M.; Ellinwood, E. H.; Boyko, O. B.; Krishnan, K. R R.

In: American Journal of Neuroradiology, Vol. 13, No. 1, 1992, p. 383-386.

Research output: Contribution to journalArticle

Doraiswamy, PM, Na, C, Husain, MM, Figiel, GS, McDonald, WM, Ellinwood, EH, Boyko, OB & Krishnan, KRR 1992, 'Morphometric changes of the human midbrain with normal aging: MR and stereologic findings', American Journal of Neuroradiology, vol. 13, no. 1, pp. 383-386.
Doraiswamy, P. M. ; Na, C. ; Husain, M. M. ; Figiel, G. S. ; McDonald, W. M. ; Ellinwood, E. H. ; Boyko, O. B. ; Krishnan, K. R R. / Morphometric changes of the human midbrain with normal aging : MR and stereologic findings. In: American Journal of Neuroradiology. 1992 ; Vol. 13, No. 1. pp. 383-386.
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