Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension

L. B. Devries, R. J. Heyne, C. Ramaciotti, L. S. Brown, M. A. Jaleel, V. S. Kapadia, P. J. Burchfield, L. P. Brion

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.

Original languageEnglish (US)
Pages (from-to)1043-1046
Number of pages4
JournalJournal of Perinatology
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

Bronchopulmonary Dysplasia
Infant Mortality
Pulmonary Hypertension
Odds Ratio
Confidence Intervals
Mortality
Gestational Age
Birth Weight
Premature Infants
Lung Diseases
Logistic Models
Regression Analysis
Parturition
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension. / Devries, L. B.; Heyne, R. J.; Ramaciotti, C.; Brown, L. S.; Jaleel, M. A.; Kapadia, V. S.; Burchfield, P. J.; Brion, L. P.

In: Journal of Perinatology, Vol. 37, No. 9, 01.09.2017, p. 1043-1046.

Research output: Contribution to journalArticle

@article{c11d42f07a19455a878555253f6a6a1e,
title = "Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension",
abstract = "Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6{\%}) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95{\%} confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95{\%} CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95{\%} CI: 2.1, 415), major surgery (aOR; 2.8, 95{\%} CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95{\%} CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.",
author = "Devries, {L. B.} and Heyne, {R. J.} and C. Ramaciotti and Brown, {L. S.} and Jaleel, {M. A.} and Kapadia, {V. S.} and Burchfield, {P. J.} and Brion, {L. P.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1038/jp.2017.89",
language = "English (US)",
volume = "37",
pages = "1043--1046",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension

AU - Devries, L. B.

AU - Heyne, R. J.

AU - Ramaciotti, C.

AU - Brown, L. S.

AU - Jaleel, M. A.

AU - Kapadia, V. S.

AU - Burchfield, P. J.

AU - Brion, L. P.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.

AB - Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.

UR - http://www.scopus.com/inward/record.url?scp=85032709536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032709536&partnerID=8YFLogxK

U2 - 10.1038/jp.2017.89

DO - 10.1038/jp.2017.89

M3 - Article

VL - 37

SP - 1043

EP - 1046

JO - Journal of Perinatology

JF - Journal of Perinatology

SN - 0743-8346

IS - 9

ER -