Mortality at long-term follow-up of patients with no, nonobstructive, and revascularized 1-, 2-, and 3-vessel obstructive coronary artery disease

Kiran Chilappa, Wilbert S. Aronow, Archana Rajdev, Chul Ahn, Kumar Kalapatapu, Anthony L. Pucillo, Craig E. Monsen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: To investigate the 5-year survival of patients with coronary angiographic evidence of no coronary artery disease (CAD), nonobstructive CAD, and revascularized 1-vessel, 2-vessel, and 3-vessel obstructive CAD. Material/Methods: Coronary angiography was performed in 2,057 unselected patients, mean age 69 years (57% men and 43% women), with an acute coronary syndrome (50%) or anginal chest pain.(50%). Results: Of 2,057 patients, 760 (37%) had obstructive CAD with >50% obstruction of at least 1 major coronary artery (left anterior descending, left circumflex, and right coronary) and were revascularized, 695 (34%) had nonobstructive CAD (<50% obstruction), and 602 (29%) had normal coronary arteries. At 60±16-month follow-up, all-cause mortality occurred in 41 of 602 patients (7%) with no CAD (group 1), in 80 of 695 patients (12%) with nonobstructive CAD (group 2), in 50 of 302 patients (17%) with revascularized 1-vessel obstructive CAD (group 3), in 47 of 201 patients (23%) with 2-vessel revascularized obstructive CAD (group 4), and in 72 of 257 patients (28%) with 3-vessel revascularized obstructive CAD (group 4). Log-rank tests to compare survival curves among the 5 groups showed p=0.004 for groups 1 versus 2; p<0.0001 for groups 1 versus 3, 1 versus 4, 1 versus 5, 2 versus 4, and 2 versus 5; and p=0.007 for groups 3 versus 5. Conclusions: Patients with nonobstructive CAD had a worse survival than those with no CAD, a nonsignificant difference in survival than those with revascularized 1-vessel obstructive CAD, and a better survival than those with revascularized 2-vessel or 3-vessel obstructive CAD.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume16
Issue number5
StatePublished - 2010

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Coronary Artery Disease
Mortality
Survival
Coronary Vessels
Acute Coronary Syndrome
Coronary Angiography
Chest Pain

Keywords

  • Anginal chest pain
  • Coronary angiography
  • Obstructive CAD

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mortality at long-term follow-up of patients with no, nonobstructive, and revascularized 1-, 2-, and 3-vessel obstructive coronary artery disease. / Chilappa, Kiran; Aronow, Wilbert S.; Rajdev, Archana; Ahn, Chul; Kalapatapu, Kumar; Pucillo, Anthony L.; Monsen, Craig E.

In: Medical Science Monitor, Vol. 16, No. 5, 2010.

Research output: Contribution to journalArticle

Chilappa, Kiran ; Aronow, Wilbert S. ; Rajdev, Archana ; Ahn, Chul ; Kalapatapu, Kumar ; Pucillo, Anthony L. ; Monsen, Craig E. / Mortality at long-term follow-up of patients with no, nonobstructive, and revascularized 1-, 2-, and 3-vessel obstructive coronary artery disease. In: Medical Science Monitor. 2010 ; Vol. 16, No. 5.
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abstract = "Background: To investigate the 5-year survival of patients with coronary angiographic evidence of no coronary artery disease (CAD), nonobstructive CAD, and revascularized 1-vessel, 2-vessel, and 3-vessel obstructive CAD. Material/Methods: Coronary angiography was performed in 2,057 unselected patients, mean age 69 years (57{\%} men and 43{\%} women), with an acute coronary syndrome (50{\%}) or anginal chest pain.(50{\%}). Results: Of 2,057 patients, 760 (37{\%}) had obstructive CAD with >50{\%} obstruction of at least 1 major coronary artery (left anterior descending, left circumflex, and right coronary) and were revascularized, 695 (34{\%}) had nonobstructive CAD (<50{\%} obstruction), and 602 (29{\%}) had normal coronary arteries. At 60±16-month follow-up, all-cause mortality occurred in 41 of 602 patients (7{\%}) with no CAD (group 1), in 80 of 695 patients (12{\%}) with nonobstructive CAD (group 2), in 50 of 302 patients (17{\%}) with revascularized 1-vessel obstructive CAD (group 3), in 47 of 201 patients (23{\%}) with 2-vessel revascularized obstructive CAD (group 4), and in 72 of 257 patients (28{\%}) with 3-vessel revascularized obstructive CAD (group 4). Log-rank tests to compare survival curves among the 5 groups showed p=0.004 for groups 1 versus 2; p<0.0001 for groups 1 versus 3, 1 versus 4, 1 versus 5, 2 versus 4, and 2 versus 5; and p=0.007 for groups 3 versus 5. Conclusions: Patients with nonobstructive CAD had a worse survival than those with no CAD, a nonsignificant difference in survival than those with revascularized 1-vessel obstructive CAD, and a better survival than those with revascularized 2-vessel or 3-vessel obstructive CAD.",
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T1 - Mortality at long-term follow-up of patients with no, nonobstructive, and revascularized 1-, 2-, and 3-vessel obstructive coronary artery disease

AU - Chilappa, Kiran

AU - Aronow, Wilbert S.

AU - Rajdev, Archana

AU - Ahn, Chul

AU - Kalapatapu, Kumar

AU - Pucillo, Anthony L.

AU - Monsen, Craig E.

PY - 2010

Y1 - 2010

N2 - Background: To investigate the 5-year survival of patients with coronary angiographic evidence of no coronary artery disease (CAD), nonobstructive CAD, and revascularized 1-vessel, 2-vessel, and 3-vessel obstructive CAD. Material/Methods: Coronary angiography was performed in 2,057 unselected patients, mean age 69 years (57% men and 43% women), with an acute coronary syndrome (50%) or anginal chest pain.(50%). Results: Of 2,057 patients, 760 (37%) had obstructive CAD with >50% obstruction of at least 1 major coronary artery (left anterior descending, left circumflex, and right coronary) and were revascularized, 695 (34%) had nonobstructive CAD (<50% obstruction), and 602 (29%) had normal coronary arteries. At 60±16-month follow-up, all-cause mortality occurred in 41 of 602 patients (7%) with no CAD (group 1), in 80 of 695 patients (12%) with nonobstructive CAD (group 2), in 50 of 302 patients (17%) with revascularized 1-vessel obstructive CAD (group 3), in 47 of 201 patients (23%) with 2-vessel revascularized obstructive CAD (group 4), and in 72 of 257 patients (28%) with 3-vessel revascularized obstructive CAD (group 4). Log-rank tests to compare survival curves among the 5 groups showed p=0.004 for groups 1 versus 2; p<0.0001 for groups 1 versus 3, 1 versus 4, 1 versus 5, 2 versus 4, and 2 versus 5; and p=0.007 for groups 3 versus 5. Conclusions: Patients with nonobstructive CAD had a worse survival than those with no CAD, a nonsignificant difference in survival than those with revascularized 1-vessel obstructive CAD, and a better survival than those with revascularized 2-vessel or 3-vessel obstructive CAD.

AB - Background: To investigate the 5-year survival of patients with coronary angiographic evidence of no coronary artery disease (CAD), nonobstructive CAD, and revascularized 1-vessel, 2-vessel, and 3-vessel obstructive CAD. Material/Methods: Coronary angiography was performed in 2,057 unselected patients, mean age 69 years (57% men and 43% women), with an acute coronary syndrome (50%) or anginal chest pain.(50%). Results: Of 2,057 patients, 760 (37%) had obstructive CAD with >50% obstruction of at least 1 major coronary artery (left anterior descending, left circumflex, and right coronary) and were revascularized, 695 (34%) had nonobstructive CAD (<50% obstruction), and 602 (29%) had normal coronary arteries. At 60±16-month follow-up, all-cause mortality occurred in 41 of 602 patients (7%) with no CAD (group 1), in 80 of 695 patients (12%) with nonobstructive CAD (group 2), in 50 of 302 patients (17%) with revascularized 1-vessel obstructive CAD (group 3), in 47 of 201 patients (23%) with 2-vessel revascularized obstructive CAD (group 4), and in 72 of 257 patients (28%) with 3-vessel revascularized obstructive CAD (group 4). Log-rank tests to compare survival curves among the 5 groups showed p=0.004 for groups 1 versus 2; p<0.0001 for groups 1 versus 3, 1 versus 4, 1 versus 5, 2 versus 4, and 2 versus 5; and p=0.007 for groups 3 versus 5. Conclusions: Patients with nonobstructive CAD had a worse survival than those with no CAD, a nonsignificant difference in survival than those with revascularized 1-vessel obstructive CAD, and a better survival than those with revascularized 2-vessel or 3-vessel obstructive CAD.

KW - Anginal chest pain

KW - Coronary angiography

KW - Obstructive CAD

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VL - 16

JO - Medical Science Monitor

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