Mortality of first-time amputees in diabetics: A 10-year observation

Yuki Izumi, Kathleen Satterfield, Shuko Lee, Lawrence B. Harkless, Lawrence A. Lavery

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Aims: We analyze mortality of first-time diabetic amputees by stratifying by level of amputation, differentiating short-term and long-term mortality. Methods: We evaluated 277 diabetic patients who received their first lower extremity amputation (LEA) during 1993-97. Subjects were followed until December 2003, and categorized by level of amputation. We compared the mortality difference by level for 0-10 years, 0-10 months, and 10 months-10 years, and examined the association of comorbid conditions and death for each level. Results: We found a significant difference in mortality by amputation level for 0-10 years (p < 0.05) and < 10 months (p < 0.01) survival, but not for the one of 10 months-10 years. For major amputees deceased within 10 months, sepsis was as frequent a cause of death as cardiovascular disease. In distal amputees, CVD, CAD and ESRD were strongly associated with death, but only CAD was associated death among major amputees. Conclusion: For diabetic patients undergoing first LEAs, the mortality of major amputees was worse than that of minor amputees due to the difference in first 10-month mortality. The history of comorbid conditions in first-time major amputees was less important than in minor amputees since sepsis was the frequent cause of death in major amputees in this early period.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume83
Issue number1
DOIs
StatePublished - Jan 2009

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Amputees
antineoplaston A10
Observation
Mortality
Amputation
Cause of Death
Sepsis
Chronic Kidney Failure
Lower Extremity
Cardiovascular Diseases
History
Survival

Keywords

  • Amputation
  • Diabetic foot
  • Mortality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

Mortality of first-time amputees in diabetics : A 10-year observation. / Izumi, Yuki; Satterfield, Kathleen; Lee, Shuko; Harkless, Lawrence B.; Lavery, Lawrence A.

In: Diabetes Research and Clinical Practice, Vol. 83, No. 1, 01.2009, p. 126-131.

Research output: Contribution to journalArticle

Izumi, Yuki ; Satterfield, Kathleen ; Lee, Shuko ; Harkless, Lawrence B. ; Lavery, Lawrence A. / Mortality of first-time amputees in diabetics : A 10-year observation. In: Diabetes Research and Clinical Practice. 2009 ; Vol. 83, No. 1. pp. 126-131.
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