Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

K. J. Hatanpaa, D. M. Blass, O. Pletnikova, B. J. Crain, E. H. Bigio, J. C. Hedreen, C. L. White, J. C. Troncoso

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67 Scopus citations

Abstract

Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalNeurology
Volume63
Issue number3
DOIs
StatePublished - Aug 10 2004

ASJC Scopus subject areas

  • Clinical Neurology

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    Hatanpaa, K. J., Blass, D. M., Pletnikova, O., Crain, B. J., Bigio, E. H., Hedreen, J. C., White, C. L., & Troncoso, J. C. (2004). Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology, 63(3), 538-542. https://doi.org/10.1212/01.WNL.0000129543.46734.C0