Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

K. J. Hatanpaa, D. M. Blass, O. Pletnikova, B. J. Crain, E. H. Bigio, J. C. Hedreen, C. L. White, J. C. Troncoso

Research output: Contribution to journalArticle

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Abstract

Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalNeurology
Volume63
Issue number3
StatePublished - Aug 10 2004

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Frontotemporal Dementia
Sclerosis
Dementia
Motor Neuron Disease
Brain Diseases
Autopsy
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hatanpaa, K. J., Blass, D. M., Pletnikova, O., Crain, B. J., Bigio, E. H., Hedreen, J. C., ... Troncoso, J. C. (2004). Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology, 63(3), 538-542.

Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. / Hatanpaa, K. J.; Blass, D. M.; Pletnikova, O.; Crain, B. J.; Bigio, E. H.; Hedreen, J. C.; White, C. L.; Troncoso, J. C.

In: Neurology, Vol. 63, No. 3, 10.08.2004, p. 538-542.

Research output: Contribution to journalArticle

Hatanpaa, KJ, Blass, DM, Pletnikova, O, Crain, BJ, Bigio, EH, Hedreen, JC, White, CL & Troncoso, JC 2004, 'Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia', Neurology, vol. 63, no. 3, pp. 538-542.
Hatanpaa KJ, Blass DM, Pletnikova O, Crain BJ, Bigio EH, Hedreen JC et al. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology. 2004 Aug 10;63(3):538-542.
Hatanpaa, K. J. ; Blass, D. M. ; Pletnikova, O. ; Crain, B. J. ; Bigio, E. H. ; Hedreen, J. C. ; White, C. L. ; Troncoso, J. C. / Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. In: Neurology. 2004 ; Vol. 63, No. 3. pp. 538-542.
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