Motor coordination deficits in mice lacking RGS9

Jacqueline Blundell; Chau V. Hoang; Bryan Potts; Stephen J. Gold; Craig M. Powell

doi:10.1016/j.brainres.2007.11.017

Motor coordination deficits in mice lacking RGS9

Jacqueline Blundell, Chau V. Hoang, Bryan Potts, Stephen J. Gold, Craig M. Powell

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.

Original language	English (US)
Pages (from-to)	78-85
Number of pages	8
Journal	Brain Research
Volume	1190
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2007.11.017
State	Published - Jan 23 2008

Keywords

Delayed-match-to-place water maze
Dopamine
Motor coordination
RGS9
Striatum
Working memory

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2007.11.017

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title = "Motor coordination deficits in mice lacking RGS9",

abstract = "RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.",

keywords = "Delayed-match-to-place water maze, Dopamine, Motor coordination, RGS9, Striatum, Working memory",

author = "Jacqueline Blundell and Hoang, {Chau V.} and Bryan Potts and Gold, {Stephen J.} and Powell, {Craig M.}",

note = "Funding Information: Supported by grants from the National Institute of Mental Health (K08 MH065975-04), NARSAD, and Autism Speaks (all to C.M.P.).",

year = "2008",

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doi = "10.1016/j.brainres.2007.11.017",

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AU - Blundell, Jacqueline

AU - Hoang, Chau V.

AU - Potts, Bryan

AU - Gold, Stephen J.

AU - Powell, Craig M.

N1 - Funding Information: Supported by grants from the National Institute of Mental Health (K08 MH065975-04), NARSAD, and Autism Speaks (all to C.M.P.).

PY - 2008/1/23

Y1 - 2008/1/23

N2 - RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.

AB - RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.

KW - Delayed-match-to-place water maze

KW - Dopamine

KW - Motor coordination

KW - RGS9

KW - Striatum

KW - Working memory

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Motor coordination deficits in mice lacking RGS9

Abstract

Keywords

ASJC Scopus subject areas

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