Motor coordination deficits in mice lacking RGS9

Jacqueline Blundell, Chau V. Hoang, Bryan Potts, Stephen J. Gold, Craig M. Powell

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalBrain Research
Volume1190
Issue number1
DOIs
StatePublished - Jan 23 2008

Keywords

  • Delayed-match-to-place water maze
  • Dopamine
  • Motor coordination
  • RGS9
  • Striatum
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Blundell, J., Hoang, C. V., Potts, B., Gold, S. J., & Powell, C. M. (2008). Motor coordination deficits in mice lacking RGS9. Brain Research, 1190(1), 78-85. https://doi.org/10.1016/j.brainres.2007.11.017