Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease

Roy N. Alcalay, Helen Mejia-Santana, Ming Xin Tang, Llency Rosado, Miguel Verbitsky, Sergey Kisselev, Barbara M. Ross, Elan D. Louis, Cynthia L. Comella, Amy Colcher, Danna Jennings, Martha A. Nance, Susan Bressman, William K. Scott, Caroline Tanner, Susan F. Mickel, Howard F. Andrews, Cheryl H. Waters, Stanley Fahn, Lucien J. CoteSteven J. Frucht, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. Friedman, Ronald Pfeiffer, Laura Marsh, Bradley Hiner, Andrew Siderowf, Elise Caccappolo, Ruth Ottman, Lorraine N. Clark, Karen S. Marder

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Objective: To determine the motor phenotype of LRRK2 G2019S mutation carriers. LRRK2 mutation carriers were previously reported to manifest the tremor dominant motor phenotype, which has been associated with slower motor progression and less cognitive impairment compared with the postural instability and gait difficulty (PIGD) phenotype. Design: Cross-sectional observational study. Setting: Thirteen movement disorders centers. Participants: Nine hundred twenty-five early-onset Parkinson disease cases defined as age at onset younger than 51 years. Main Outcome Measures: LRRK2 mutation status and Parkinson disease motor phenotype: tremor dominant or PIGD. Demographic information, family history of Parkinson disease, and the Unified Parkinson's Disease Rating Scale score were collected on all participants. DNA samples were genotyped for LRRK2 mutations (G2019S, I2020T, R1441C, and Y1699C). Logistic regression was used to examine associations of G2019S mutation status with motor phenotype adjusting for disease duration, Ashkenazi Jewish ancestry, levodopa dose, and family history of Parkinson disease. Results: Thirty-four cases (3.7%) (14 previously reported) were G2019S carriers. No other mutations were found. Carriers were more likely to be Ashkenazi Jewish (55.9% vs 11.9%; P<.001) but did not significantly differ in any other demographic or disease characteristics. Carriers had a lower tremor score (P=.03) and were more likely to have a PIGD phenotype (92.3% vs 58.9%; P=.003). The association of the G2019S mutation with PIGD phenotype remained after controlling for disease duration and Ashkenazi Jewish ancestry (odds ratio, 17.7; P<.001). Conclusion: Early-onset Parkinson disease G2019S LRRK2 carriers are more likely to manifest the PIGD phenotype, which may have implications for disease course.

Original languageEnglish (US)
Pages (from-to)1517-1522
Number of pages6
JournalArchives of neurology
Volume66
Issue number12
DOIs
StatePublished - Dec 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Alcalay, R. N., Mejia-Santana, H., Tang, M. X., Rosado, L., Verbitsky, M., Kisselev, S., Ross, B. M., Louis, E. D., Comella, C. L., Colcher, A., Jennings, D., Nance, M. A., Bressman, S., Scott, W. K., Tanner, C., Mickel, S. F., Andrews, H. F., Waters, C. H., Fahn, S., ... Marder, K. S. (2009). Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease. Archives of neurology, 66(12), 1517-1522. https://doi.org/10.1001/archneurol.2009.267