Mouse fibroblasts A9 are deficient in HPRT and APRT

R. P. Cox; M. R. Krauss; M. E. Balis; J. Dancis

Mouse fibroblasts A9 are deficient in HPRT and APRT

R. P. Cox, M. R. Krauss, M. E. Balis, J. Dancis

Research output: Contribution to journal › Article › peer-review

Abstract

The A9 cell line, frequently used for cell hybridization, is deficient in both HPRT and APRT. Evidently the parent L cell line from which A9 was derived had previously undergone a spontaneous mutation to APRT deficiency. The double enzyme deficiency in A9 cells should be recognized by investigators who use this line for studies on somatic cell genetics.

Original language	English (US)
Pages (from-to)	272-273
Number of pages	2
Journal	American Journal of Human Genetics
Volume	26
Issue number	2
State	Published - Jan 1 1974

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "Mouse fibroblasts A9 are deficient in HPRT and APRT",

abstract = "The A9 cell line, frequently used for cell hybridization, is deficient in both HPRT and APRT. Evidently the parent L cell line from which A9 was derived had previously undergone a spontaneous mutation to APRT deficiency. The double enzyme deficiency in A9 cells should be recognized by investigators who use this line for studies on somatic cell genetics.",

author = "Cox, {R. P.} and Krauss, {M. R.} and Balis, {M. E.} and J. Dancis",

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AU - Krauss, M. R.

AU - Balis, M. E.

AU - Dancis, J.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - The A9 cell line, frequently used for cell hybridization, is deficient in both HPRT and APRT. Evidently the parent L cell line from which A9 was derived had previously undergone a spontaneous mutation to APRT deficiency. The double enzyme deficiency in A9 cells should be recognized by investigators who use this line for studies on somatic cell genetics.

AB - The A9 cell line, frequently used for cell hybridization, is deficient in both HPRT and APRT. Evidently the parent L cell line from which A9 was derived had previously undergone a spontaneous mutation to APRT deficiency. The double enzyme deficiency in A9 cells should be recognized by investigators who use this line for studies on somatic cell genetics.

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Mouse fibroblasts A9 are deficient in HPRT and APRT

Abstract

ASJC Scopus subject areas

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