Mouse models as tools for dissecting disorders of lipoprotein metabolism

Peter Marschang, Joachim Herz

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The overexpression of proteins as transgenes or by adenovirus-mediated gene transfer as well as the disruption of genes by homologous DNA recombination in the mouse provide powerful tools to dissect the role of individual proteins in complex biological pathways. These and similar techniques have been widely used to characterize the function of most of the players involved in lipoprotein metabolism. These models are expected to greatly advance the finding of new therapeutic strategies for the treatment of disorders of lipoprotein metabolism.

Original languageEnglish (US)
Pages (from-to)25-35
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume14
Issue number1
DOIs
StatePublished - Feb 2003

Keywords

  • Adenovirus-mediated gene transfer
  • Gene targeting
  • Knockout
  • Lipoprotein metabolism
  • Transgene

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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